The Journal of the Korean dental association (대한치과의사협회지)

The Korean Dental Association (대한치과의사협회)
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Bone regeneration in oral and maxillofacial field using rhBMP-2

rhBMP-2의 작용기전과 구강악안면 영역의 골재생을 위한 rhBMP-2의 활용

  • Hwang, Soon Jung (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University) ;
  • Park, Min-Woo (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University) ;
  • Park, Jae bong (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University) ;
  • Park, Hyun Soo (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University) ;
  • Paek, Seung-Jun (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University) ;
  • Sul, Hee-Kyung (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University) ;
  • Lee, Kyung jin (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University) ;
  • Hong, Dong-Hwan (Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
  • 황순정 (서울대학교 치의학대학원/치과병원 구강악안면외과) ;
  • 박민우 (서울대학교 치의학대학원/치과병원 구강악안면외과) ;
  • 박재봉 (서울대학교 치의학대학원/치과병원 구강악안면외과) ;
  • 박현수 (서울대학교 치의학대학원/치과병원 구강악안면외과) ;
  • 백승준 (서울대학교 치의학대학원/치과병원 구강악안면외과) ;
  • 설희경 (서울대학교 치의학대학원/치과병원 구강악안면외과) ;
  • 이경진 (서울대학교 치의학대학원/치과병원 구강악안면외과) ;
  • 홍동환 (서울대학교 치의학대학원/치과병원 구강악안면외과)
  • Received : 2014.11.25
  • Accepted : 2014.12.23
  • Published : 2015.01.01
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Abstract

To overcome shortcoming of autogeneous, allogenic, xenogenic and alloplastic bone grafts, various growth factors related to bone regeneration have been identified and developed. Among them, rhBMP-2 is regarded as the most potent osteoinductive growth factor and it can trigger the differentiation of mesenchymal stem cells to osteogenic cells for accelerated new bone formation And several commercial products of rhBMP-2 are available in Korea. It is applied to maxillary sinus augmentation, guided bone regeneration and preservation of extraction socket. In this review, the development, action mechanism and clinical applications of rhBMP-2 will be described.

Keywords

References

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