DOI QR코드

DOI QR Code

Inhibitory effect of mushrooms extract on TNF-α/INF-γ induced-cytokine in human keratinocytes, HaCaT

버섯류 추출물의 피부각질세포(HaCaTcell) 내 염증성 사이토카인 억제효과

  • Choi, Eun-Ju (Division of Sport Science, College of Science and Technology, Konkuk University) ;
  • Kim, Eun-Kyung (Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University) ;
  • Ji, Yong-Seok (Department of Physical Education, Cheongju University) ;
  • Lee, Chang-Jin (Division of Sport Science, College of Science and Technology, Konkuk University)
  • 최은주 (건국대학교 과학기술대학 스포츠과학부) ;
  • 김은경 (건국대학교 의료생명대학 식품생명과학부) ;
  • 지용석 (청주대학교 체육교육학과) ;
  • 이창진 (건국대학교 과학기술대학 스포츠과학부)
  • Received : 2015.08.04
  • Accepted : 2015.10.02
  • Published : 2015.09.30

Abstract

Mushroom is known for anti-inflammatory and anti-oxidative potential. This study provides evidence that the inhibitory effect of mushroom on the expression of pro-inflammatory cytokines in human keratinocytes, HaCaT cells. To define the underlying mechanisms of action, tumor necrosis factor${\alpha}$/$IFN{\gamma}$-activated human keratinocytes model was used. Mushroom significantly inhibited the expression of cytokines in HaCaT cells. Taken together, the results demonstrate that mushroom inhibited inflammtion, suggesting that mushroom (DW extract: Grifola frondosa Cordyceps militaris), (Ethanol extract: Ganoderma lucidum, Lentinus edodes, Cordyceps militaris, Flammulina velutipes) might be a candidate for the treatment of skin inflammation.

식용버섯인 팽이버섯, 꽃송이버섯, 참송이버섯, 느타리 버섯, 녹각영지, 상황버섯, 눈꽃 동충하초, 아가리쿠스, 잎새버섯, 석이버섯, 노랑느타리버섯, 분홍느타리버섯, 편각영지버섯, 현미 동충하초, 번데기 동충하초, 표고버섯의 물 및 에탄올 추출물에 대한 피부염증완화 효능을 확인한 결과 열수추출물에서는 잎새버섯과 번데기 동충하초가 피부염증완화 효능이 탁월하였으며, 에탄올 추출물에서는 영지버섯, 표고버섯, 번데기 동충하초와 팽이버섯에서 피부염증완화 효능이 탁월하였다. 특히, 각각의 추출물에서 피부염증완화 효능이 높은 것은 번데기 동충하초 임을 확인하였다.

Keywords

References

  1. Kim EJ, Kim JH. 2015. Fibrinolytic, thrombin inhibitory, antioxidative and anti-inflammatory activities of Pleurotus ferulea. Journal of Mushroom. 13(1): 30-36. https://doi.org/10.14480/JM.2015.13.1.30
  2. Kang SH 2010. Effects of Lithospermum erythrorhizon on the cytokine gene expression by P. acnes in human keratinocyte. Graduate School of Kyungwon University.
  3. Yoo JH. 2010. The effect of complex mushroom extracts on the improvement in skin conditions with atopic dermatitis and acne symptoms. Chosun University
  4. Oh DS, Wang SJ, Kim HS, Wi AJ, Yoon SY, Park HS and Park HH. 2014. Optimal medium composition of cauliflower mushroom (Sparassis latifolia) cultivation using douglas fir wood chip and comparison of the fruiting body. J Kor Wood Sci Technol. 42(4): 428-438. https://doi.org/10.5658/WOOD.2014.42.4.428
  5. O'Callaghan YC, O'Brien NM, Kenny O, Harrington, T. Brunton N, Smyth TJ. 2015. Anti-inflammatory effects of wild lrish mushroom extracts in RAW264.7 mouse macrophage cells. J Med Food. 18(2): 202-207. https://doi.org/10.1089/jmf.2014.0012
  6. Bae Jun-Tae, Song Min-Hyeon, Kim Jin-Hwa, Lee Geun-Soo, Pyo Hyeong-Bae. 2012. Production of Flavonoid Compounds and Anti-inflammatory Property of Fermented Licorice Extract with the Basidiomycete Grifola frondosa HB0071. Journal of the Society of Cosmetic Scientists of Korea. 38(4): 327-338. https://doi.org/10.15230/SCSK.2012.38.4.327

Cited by

  1. Skin-whitening effects of hot water extract from domestic edible mushrooms vol.14, pp.4, 2016, https://doi.org/10.14480/JM.2016.14.4.225