Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Clinical Characteristics and Outcomes of Acute ST-Segment Elevation Myocardial Infarction in Younger Korean Adults

  • Lee, Seung Hun (The Heart Center of Chonnam National University Hospital) ;
  • Kim, Ju Han (The Heart Center of Chonnam National University Hospital) ;
  • Jeong, Myung Ho (The Heart Center of Chonnam National University Hospital) ;
  • Park, Hyukjin (The Heart Center of Chonnam National University Hospital) ;
  • Jeong, Yun Ah (The Heart Center of Chonnam National University Hospital) ;
  • Ahn, Youngkeun (The Heart Center of Chonnam National University Hospital) ;
  • Kim, Jong Hyun (The Cardiovascular Center, Hanseo Hospital) ;
  • Chae, Shung Chull (Department of Internal Medicine, Kyungpook National University Hospital) ;
  • Kim, Young Jo (Department of Internal Medicine, Yeungnam University Hospital) ;
  • Hur, Seung Ho (Department of Internal Medicine, Keimyung University Dongsan Medical Center) ;
  • Seong, In Whan (Department of Internal Medicine, Chungnam National University Hospital) ;
  • Hong, Taek Jong (Department of Internal Medicine, Pusan National University Hospital) ;
  • Choi, Donghoon (Department of Internal Medicine, Yonsei University Severans Hospital) ;
  • Cho, Myeong Chan (Department of Internal Medicine, Chungbuk National University Hospital) ;
  • Kim, Chong Jin (Department of Internal Medicine, Kyunghee University College of Medicine) ;
  • Seung, Ki Bae (Department of Internal Medicine, The Catholic University of Korea Hospital) ;
  • Chung, Wook Sung (Department of Internal Medicine, The Catholic University of Korea Hospital) ;
  • Jang, Yang Soo (Department of Internal Medicine, Yonsei University Severans Hospital) ;
  • Cho, Jeong Gwan (The Heart Center of Chonnam National University Hospital) ;
  • Park, Jong Chun (The Heart Center of Chonnam National University Hospital) ;
  • Park, Seung Jung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Other Korea Acute Myocardial Infarction Registry Investigators (Other Korea Acute Myocardial Infarction Registry Investigators)
  • Received : 2015.03.03
  • Accepted : 2015.04.09
  • Published : 2015.07.30
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Abstract

Background and Objectives: This study aims to investigate the clinical features, angiographic findings, and outcomes of younger Korean ST-segment elevation myocardial infarction (STEMI) patients. Subjects and Methods: We analyzed major adverse cardiac events (MACE) in the Korea Acute Myocardial Infarction Registry from November 2005 to October 2010. The registered patients were divided into two groups; young age group (<65 years) and old age group (${\geq}65years$). Results: The young age group included 5281 patients (age, $53{\pm}7.8years$), and the old age group included 4896 patients (age, $74.3{\pm}6.5years$). Male gender, smoking, family history, dyslipidemia, and metabolic syndrome were more frequently observed in the young age group than in the old age group (89.5% vs. 59.3%, p<0.001; 77.3% vs. 47.2%, p<0.001; 11% vs. 4.6%, p<0.001; 11.2% vs. 7.7%, p<0.001; 67.6% vs. 62.9%, p<0.001). Most of the young Korean adults with STEMI complained of typical chest pain (89.8%), and they had a shorter symptom-to-door time ($12{\pm}53.2hours$ vs. $17.3{\pm}132hours$, p=0.010). The young age group showed a favorable prognosis, which was represented by the MACE, compared with the old age group at one month (1.8% vs. 2.8%, p=0.028), six months (6.8% vs. 8.2%, p<0.001), and twelve months (10.1% vs. 11.9%, p=0.025). However, there was no significant difference in the adjusted MACE rate at one month {hazard ratio (HR) 0.95, 95% confidence interval (CI) 0.60-1.51, p=0.828} and twelve months (HR 0.86, 95% CI 0.68-1.10, p=0.233). Conclusion: Younger Korean adults with STEMI have clinical outcomes similar to old aged patients, and therefore, they should be treated intensively like the elderly patients.

Keywords

Acknowledgement

Grant : 분자의과학 융합사업단

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