Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct

  • Guo, Jing (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology) ;
  • He, Hongjuan (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology) ;
  • Liu, Qi (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology) ;
  • Zhang, Fengwei (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology) ;
  • Lv, Jie (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology) ;
  • Zeng, Tiebo (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology) ;
  • Gu, Ning (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology) ;
  • Wu, Qiong (School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology)
  • Received : 2015.04.09
  • Accepted : 2015.07.13
  • Published : 2015.10.31
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Abstract

Most imprinted genes are concerned with embryonic development, especially placental development. Here, we identified a placenta-specific imprinted gene Qpct. Our results show that Qpct is widely expressed during early embryonic development and can be detected in the telecephalon, midbrain, and rhombencephalon at E9.5-E11.5. Moreover, Qpct is strikingly expressed in the brain, lung and liver in E15.5. Expression signals for Qpct achieved a peak at E15.5 during placental development and were only detected in the labyrinth layer in E15.5 placenta. ChIP assay results suggest that the modification of histone H3K4me3 can result in maternal activating of Qpct.

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References

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