Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Puffed Red Ginseng Power and Drink on Blood Glucose and Serum Lipid Profile in Streptozotocin-Induced Diabetic Rats

팽화홍삼 분말 및 음료 식이가 Streptozotocin 유발 당뇨쥐의 혈당 및 혈청지질에 미치는 영향

  • Received : 2015.06.11
  • Accepted : 2015.06.30
  • Published : 2015.10.31
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Abstract

This study was performed to investigate the effects of puffed-red ginseng (PRG) powder and drink on blood glucose level and serum lipid profile in streptozotocin (STZ)-induced diabetic rats. For the experimental design, STZ-induced diabetic rats were fed PRG powder-supplemented diets (0.3%, 0.6%) and diluted drinks (0.14%, 0.28%) for 6 weeks. Concentrations of blood glucose during the experimental period decreased to 18.3 mg/dL in the 0.6% PRG diet group and 15.1 mg/dL in the 0.14% PRG drink group. Average reduction rate of blood glucose in the last week compared to reference blood glucose concentration decreased by 19.2% (A group), 37.4% (B group), 18.7% (C group), and 17.3% (D group) in the PRG treatment groups, respectively. These results indicate that PRG affects blood glucose via ginseng saponins administered in diet or drinking water, thereby suggesting that PRG has the ability to prevent increasing blood glucose in mild-induced diabetic rats.

팽화홍삼 분말 및 음료 식이가 당뇨 유발쥐의 혈당 및 혈청 지질에 미치는 영향을 조사하였다. 홍삼식이는 흰쥐용 기본사료(AIN-93 diet)에 팽화홍삼 분말을 각각 0.3%와 0.6%의 중량비율(w/w)로 첨가하여 실험식이를 제조하였고, 팽화홍삼 음료는 팽화홍삼을 각각 0.14%와 0.28%의 중량비율로 음용수에 희석하여 제조하고 6주 동안 급여하였다. 시험 대조군은 당뇨 유발쥐에게 일반식이(AIN-93 diet)와 물을 급여하였다. 시험기간 동안 주별 혈당의 누적 감소치는 팽화홍삼 분말 B군(0.6%)과 팽화홍삼 음료 C군(0.14%)에서 각각 18.3, 15.1 mg/dL였고, 기준 혈당 대비 시험종료일의 혈당 감소율은 팽화홍삼 분말 B군이 37.4%, 다른 팽화홍삼투여군(A, C, D)에서는 각각 19.2, 18.7 및 17.3%로 비슷하였다. 본 연구 결과 팽화홍삼 투여군은 대조군에 비해서 실험기간 동안 혈당치의 감소에 영향을 미친 것으로 나타났고, 특히 팽화홍삼 분말 B군의 식이를 통한 사포닌 섭취량과 체중 증가, 식이효율 및 음수량 등을 고려할 때 팽화홍삼이 혈당치의 감소에 유의적인 효과를 미친 것으로 사료되었다. 이와 더불어 향후 팽화홍삼의 혈당 감소와 관련된 biomarker에 대한 보다 정밀한 연구가 필요한 것으로 사료된다.

Keywords

References

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