Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Lipid A as a Drug Target and Therapeutic Molecule

  • Joo, Sang Hoon (Laboratory of Biochemistry, College of Pharmacy, Catholic University of Daegu)
  • Received : 2015.08.02
  • Accepted : 2015.10.05
  • Published : 2015.11.01
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Abstract

In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.

Keywords

References

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