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http://dx.doi.org/10.4062/biomolther.2015.117

Lipid A as a Drug Target and Therapeutic Molecule  

Joo, Sang Hoon (Laboratory of Biochemistry, College of Pharmacy, Catholic University of Daegu)
Publication Information
Biomolecules & Therapeutics / v.23, no.6, 2015 , pp. 510-516 More about this Journal
Abstract
In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.
Keywords
Lipid A; Endotoxin; Drug target; Antibacterial; Adjuvant;
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