Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children

  • Kim, Na Yeon (Department of Pediatrics, CHA Bundang Medical Center) ;
  • Kim, Ga Ram (Department of Pediatrics, CHA Bundang Medical Center) ;
  • Kim, Joon Hwan (Department of Pediatrics, CHA Bundang Medical Center) ;
  • Baek, Ji Hyeon (Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Yoon, Jung Won (Department of Pediatrics, Myongji Hospital) ;
  • Jee, Hye Mi (Department of Pediatrics, CHA Bundang Medical Center) ;
  • Baek, Hye Sung (Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Jung, Yong Ho (Department of Pediatrics, CHA Bundang Medical Center) ;
  • Choi, Sun Hee (Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine) ;
  • Kim, Ki Eun (CHA University School of Medicine) ;
  • Shin, Youn Ho (CHA University School of Medicine) ;
  • Yum, Hye Yung (Department of Pediatrics, Seoul Medical Center) ;
  • Han, Man Yong (Department of Pediatrics, CHA Bundang Medical Center) ;
  • Kim, Kyu-Earn (Department of Pediatrics, Yonsei University College of Medicine)
  • 투고 : 2014.08.28
  • 심사 : 2014.10.30
  • 발행 : 2015.09.10
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초록

Purpose: The clinical interpretation of children sensitized to allergens is challenging, particularly in children with food allergies. We aimed to examine clinical differences between children with monosensitization and those with polysensitization to common food allergens and to determine risk factors for polysensitization in young children <10 years of age with immediate-type food allergies. Methods: The study included children <10 years of age with signs and symptoms indicative of immediate-type food allergies. Serum total IgE level was measured, and ImmunoCAP analysis for food allergens was performed. Results: The mean age of the study subjects was $1.6{\pm}1.6$ years (75 boys and 51 girls). Thirty-eight children (30.2%) were monosensitized and 88 children (69.8%) were polysensitized. Multivariate logistic regression analysis showed that the development of polysensitization to common food allergens was positively associated with a parental history of allergic rhinitis (adjusted odds ratio [aOR], 6.28; 95% confidence interval [CI], 1.78-22.13; P=0.004), season of birth (summer/fall) (aOR, 3.10; 95% CI, 1.10-8.79; P=0.033), and exclusive breastfeeding in the first 6 months of age (aOR, 3.51; 95% CI, 1.20-10.25; P=0.022). Conclusion: We found significant clinical differences between children with monosensitization and those with polysensitization to common food allergens and identified risk factors for the development of polysensitization in young children with immediate-type food allergies. Clinicians should consider these clinical risk factors when evaluating, counseling, treating, and monitoring young children with food allergies.

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참고문헌

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피인용 문헌

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  2. Proper allergen selection for serum specific IgE test in children vol.6, pp.5, 2018, https://doi.org/10.4168/aard.2018.6.5.237