Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Vitamin D serum levels in children with allergic and vasomotor rhinitis

  • Lee, Seung Jin (Department of Pediatrics, Kyungpook National University School of Medicine) ;
  • Kang, Bong Hwa (Department of Pediatrics, Kyungpook National University School of Medicine) ;
  • Choi, Bong Seok (Department of Pediatrics, Kyungpook National University School of Medicine)
  • 투고 : 2014.08.01
  • 심사 : 2014.10.30
  • 발행 : 2015.09.10
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초록

Purpose: In addition to regulating calcium and phosphorus homeostasis and bone metabolism, vitamin D is known as an immune modulator. Recently, there has been increased worldwide interest in the association between low levels of vitamin D and allergic diseases. The purpose of this study was to assess the relationship between serum vitamin D levels and allergic/vasomotor rhinitis (AR/VR) in children. Methods: This study included 164 patients. The sample included 59 patients with AR, 42 patients with VR, and 63 controls. Their ages ranged from 0 to 16 years. We examined the levels of 25-hydroxyvitamin D, Immunoglobulin E, specific IgE, and eosinophil cationic protein; peripheral blood eosinophil count; and the results of a skin prick test. Results: Serum 25-hydroxyvitamin D levels were $19.0{\pm}8.5ng/mL$ in the AR group, $25.5{\pm}10.9ng/mL$ in the VR group, and $26.9{\pm}10.7ng/mL$ in the control group. After adjustment for body mass index and season at the time of blood sampling, vitamin D levels in the AR group were lower than those of the VR group (P=0.003) and control group (P<0.001). Vitamin D levels were inversely correlated with Immunoglobulin E levels (r=-0.317, P<0.001). AR patients with food allergy or atopic dermatitis did not have lower levels of 25-hydroxyvitamin D than AR patients without these diseases. Conclusion: This study demonstrates a possible relationship between vitamin D levels and allergic rhinitis in Korean children.

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참고문헌

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피인용 문헌

  1. Suboptimal vitamin D status in Korean adolescents: a nationwide study on its prevalence, risk factors including cotinine-verified smoking status and association with atopic dermatitis and asthma vol.7, pp.7, 2017, https://doi.org/10.1136/bmjopen-2017-016409
  2. The Relationship between Serum Vitamin D Levels with Allergic Rhinitis Incidence and Total Nasal Symptom Score in Allergic Rhinitis Patients vol.6, pp.8, 2018, https://doi.org/10.3889/oamjms.2018.247
  3. The role of vitamin D in obstructive sleep apnoea syndrome vol.14, pp.3, 2015, https://doi.org/10.1183/20734735.000618
  4. The Impact of Serum 25-Hydroxyvitamin D3 Levels on Allergic Rhinitis vol.100, pp.5, 2015, https://doi.org/10.1177/0145561319874310