Molecules and Cells

  • 제38권9호
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  • Pages.759-764
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  • 2015
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation

  • Lee, Na-Rae (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Kim, Hye-In (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Choi, Myung-Soo (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Yi, Chae-Min (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Inn, Kyung-Soo (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University)
  • 투고 : 2015.03.17
  • 심사 : 2015.07.01
  • 발행 : 2015.09.30
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초록

Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated activation of NF-${\kappa}B$ and interferon production. TRIM25 is required for the full activation of NF-${\kappa}B$ at the downstream of MAVS, while it is not involved in IRF3 nuclear translocation. Mechanical studies showed that TRIM25 is involved in TRAF6-mediated NF-${\kappa}B$ activation. These collectively indicate that TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-${\kappa}B$.

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참고문헌

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  4. Ubiquitin in the activation and attenuation of innate antiviral immunity vol.213, pp.1, 2016, https://doi.org/10.1084/jem.20151531
  5. The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination vol.91, pp.8, 2017, https://doi.org/10.1128/JVI.02143-16
  6. Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome vol.14, pp.1, 2018, https://doi.org/10.1371/journal.ppat.1006852
  7. TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer vol.37, pp.16, 2018, https://doi.org/10.1038/s41388-017-0095-x
  8. USP4 positively regulates RLR-induced NF-κB activation by targeting TRAF6 for K48-linked deubiquitination and inhibits enterovirus 71 replication vol.8, pp.1, 2018, https://doi.org/10.1038/s41598-018-31734-6
  9. Gene in Chinese Patients with Dyschromatosis Symmetrica Hereditaria vol.22, pp.2, 2018, https://doi.org/10.1089/gtmb.2017.0207
  10. OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses vol.41, pp.3, 2015, https://doi.org/10.14348/molcells.2018.2293
  11. To TRIM the Immunity: From Innate to Adaptive Immunity vol.11, pp.None, 2015, https://doi.org/10.3389/fimmu.2020.02157
  12. TRIM25 Promotes TNF-α–Induced NF-κB Activation through Potentiating the K63-Linked Ubiquitination of TRAF2 vol.204, pp.6, 2015, https://doi.org/10.4049/jimmunol.1900482
  13. TRIM25 and its emerging RNA‐binding roles in antiviral defense vol.11, pp.4, 2015, https://doi.org/10.1002/wrna.1588
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