YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Serotonin as a Possible Modulator of Impulsive Behavior in Wistar Rats

위스타 랫드의 충동성 조절에 대한 세로토닌의 역할

  • Kim, Chong Ah (Uimyung Research Institute for Neuroscience, Sahmyook University) ;
  • Cheong, Jae Hoon (Uimyung Research Institute for Neuroscience, Sahmyook University)
  • 김정아 (삼육대학교 의명신경과학연구소) ;
  • 정재훈 (삼육대학교 의명신경과학연구소)
  • Received : 2015.07.10
  • Accepted : 2015.08.04
  • Published : 2015.08.30
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Abstract

We compared impulsive behaviors in Wistar rats and in Wistar-Kyoto rats. There was no significant difference in locomotor activity between them. However, Wistar rats showed high activity in 5-choice serial reaction time track. When Wistar rats were treated with atomoxetin (3 mg/kg), methylphenidate (2 mg/kg) or amphetamine (2 mg/kg), they showed less impulsive behavior. Serotonin contents in prefrontal cortex and brain stem also increased. In conclusion, we suggest that Wistar rats could be used as animal model for impulsive behavior analysis. In addition, serotonin might be related with this impulsivity.

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References

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