Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Analysis of Prethrombotic States in Patients with Malignant Tumors

  • Cui, Lin (Department of Oncology, Taizhou Second People’s Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Sun, You-Hong (Department of Oncology, Taizhou Second People’s Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Chen, Jue (Meidicall college of Yangzhou University) ;
  • Wang, Lu (Department of Oncology, Taizhou Second People’s Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Liu, Jian-Jun (Department of Oncology, Taizhou Second People’s Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Zhou, Xiang-Rong (Department of Oncology, Taizhou Second People’s Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Ding, Jie (Department of Oncology, Taizhou Second People’s Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Liu, Xing-Xiang (Department of Oncology, Taizhou Second People’s Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Huang, Xin-En (Department of Chemotherapy, Affiliated Jiangsu Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research)
  • Published : 2015.08.03
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Abstract

Background: This study aimed to investigate the incidence and risk factors for a prethrombotic state in patients with malignant tumors. Materials and Methods: Plasma d-dimer (D-D) in patients with malignant tumors was measured. Abnormal rates of D-D and possible risk factors like gender, age, type of tumor, and staging of tumor were analyzed. Results: Of 1,453 patients, 629 demonstrated plasma D-D abnormality (43.3%). The D-D abnormal rate of male patients (n=851, 43.5%) was not statistically significantly different from that for female patients (n=602, 43.0%) (p>0.05). D-D abnormal rate increased with age and was statistically significant among different age groups (p<0.05). Regarding staging of tumor, D-D abnormal rate in patients with phase I was 2.0%, 6.2% in phase II, 47.6% in phase III and 83.1% in phase IV, with statistically significant differences between phase III and II, as well as phase III and IV (p<0.01). Conclusions: A prethrombotic state was closely related to malignancy of tumors. The risk factors for a prethrombotic state include age and tumor stage.

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References

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