Asian Pacific Journal of Cancer Prevention

  • 제16권9호
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  • Pages.3773-3777
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  • 2015
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Establishing a Nomogram for Stage IA-IIB Cervical Cancer Patients after Complete Resection

  • Zhou, Hang (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Li, Xiong (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Zhang, Yuan (Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Jia, Yao (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Hu, Ting (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Yang, Ru (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Huang, Ke-Cheng (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Chen, Zhi-Lan (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Wang, Shao-Shuai (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Tang, Fang-Xu (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Zhou, Jin (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Chen, Yi-Le (Department of Gynecologic Neoplasms, Hunan Province Tumor Hospital, The Affiliated Tumor Hospital of Central South University) ;
  • Wu, Li (Department of Gynecologic Neoplasms, Hunan Province Tumor Hospital, The Affiliated Tumor Hospital of Central South University) ;
  • Han, Xiao-Bing (The First Affiliated Hospital, Medical School of Xi'an Jiaotong University) ;
  • Lin, Zhong-Qiu (The Second Affiliated Hospital, Sun Yat-sen University) ;
  • Lu, Xiao-Mei (The Second Affiliated Hospital, Sun Yat-sen University) ;
  • Xing, Hui (Xiangyang Central Hospital, First Affiliated Hospital of Hubei University of Arts and Science) ;
  • Qu, Peng-Peng (Tianjin Central Hospital for Gynecology and Obstetrics) ;
  • Cai, Hong-Bing (Zhong Nan Hospital, Wuhan University) ;
  • Song, Xiao-Jie (Commercial Vocational Hospital) ;
  • Tian, Xiao-Yu (The First Affiliated Hospital of Henan University of Science and Technology) ;
  • Zhang, Qing-Hua (The Central Hospital of Wuhan) ;
  • Shen, Jian (The Central Hospital of Wuhan) ;
  • Liu, Dan (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Wang, Ze-Hua (Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Xu, Hong-Bing (Shenzhen People's Hospital, the Second Clinical Hospital of Jinan University) ;
  • Wang, Chang-Yu (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Xi, Ling (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Deng, Dong-Rui (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Wang, Hui (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Lv, Wei-Guo (Women's Reproductive Health Laboratory of Zhejiang Province) ;
  • Shen, Keng (Department Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College) ;
  • Wang, Shi-Xuan (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Xie, Xing (Women's Reproductive Health Laboratory of Zhejiang Province) ;
  • Cheng, Xiao-Dong (Women's Reproductive Health Laboratory of Zhejiang Province) ;
  • Ma, Ding (Department of Obstetrics and Gynecology, Tongji Hospital) ;
  • Li, Shuang (Department of Obstetrics and Gynecology, Tongji Hospital)
  • 발행 : 2015.05.18
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초록

Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection with pelvic lymphadenectomy. Materials and Methods: This nomogram was based on a retrospective study on 1,563 stage IA-IIB cervical cancer patients who underwent complete resection and lymphadenectomy from 2002 to 2008. The nomogram was constructed based on multivariate analysis using Cox proportional hazard regression. The accuracy and discriminative ability of the nomogram were measured by concordance index (C-index) and calibration curve. Results: Multivariate analysis identified lymph node metastasis (LNM), lymph-vascular space invasion (LVSI), stromal invasion, parametrial invasion, tumor diameter and histology as independent prognostic factors associated with cervical cancer survival. These factors were selected for construction of the nomogram. The C-index of the nomogram was 0.71 (95% CI, 0.65 to 0.77), and calibration of the nomogram showed good agreement between the 5-year predicted survival and the actual observation. Conclusions: We developed a nomogram predicting 5-year overall survival of surgically treated stage IA-IIB cervical cancer patients. More comprehensive information that is provided by this nomogram could provide further insight into personalized therapy selection.

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참고문헌

  1. Bochner BH, Kattan MW, Vora KC (2006). Postoperative nomogram predicting risk of recurrence after radical cystectomy for bladder cancer. J Clin Oncol, 24, 3967-72. https://doi.org/10.1200/JCO.2005.05.3884
  2. Chang SJ, Kim WY, Yoo SC, et al (2009). A validation study of new risk grouping criteria for postoperative treatment in stage IB cervical cancers without high-risk factors: rethinking the gynecologic oncology group criteria. Eur J Obstet Gynecol Reprod Biol, 147, 91-6. https://doi.org/10.1016/j.ejogrb.2009.07.013
  3. Creasman WT, Kohler MF (2004). Is lymph vascular space involvement an independent prognostic factor in early cervical cancer? Gynecol Oncol, 92, 525-9. https://doi.org/10.1016/j.ygyno.2003.11.020
  4. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
  5. Grochola LF, Greither T, Taubert H, et al (2008). The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. Br J Cancer, 99, 1083-8. https://doi.org/10.1038/sj.bjc.6604653
  6. Han DS, Suh YS, Kong SH, et al (2012). Nomogram predicting long-term survival after d2 gastrectomy for gastric cancer. J Clin Oncol, 30, 3834-40. https://doi.org/10.1200/JCO.2012.41.8343
  7. Harrell FE, Jr., Lee KL, Mark DB (1996). Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med, 15, 361-87. https://doi.org/10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4
  8. Harrell FE Jr (2001). Regression modeling strategies with applications to linear models LR, and survival analysis, volume 19. New York, NY, Springer-Verlag.
  9. Ho CM, Chien TY, Huang SH, et al (2004). Multivariate analysis of the prognostic factors and outcomes in early cervical cancer patients undergoing radical hysterectomy. Gynecol Oncol, 93, 458-64. https://doi.org/10.1016/j.ygyno.2004.01.026
  10. Hricak H, Gatsonis C, Chi DS, et al (2005). Role of imaging in pretreatment evaluation of early invasive cervical cancer: results of the intergroup study American college of radiology imaging network 6651-gynecologic oncology group 183. J Clin Oncol, 23, 9329-37. https://doi.org/10.1200/JCO.2005.02.0354
  11. Hu T, Li S, Chen Y, et al (2012). Matched-case comparison of neoadjuvant chemotherapy in patients with FIGO stage IB1-IIB cervical cancer to establish selection criteria. Eur J Cancer, 48, 2353-60. https://doi.org/10.1016/j.ejca.2012.03.015
  12. Hu T, Wu L, Xing H, et al (2013). Development of criteria for ovarian preservation in cervical cancer patients treated with radical surgery with or without neoadjuvant chemotherapy: a multicenter retrospective study and meta-analysis. Ann Surg Oncol, 20, 881-90. https://doi.org/10.1245/s10434-012-2632-8
  13. Huitzil-Melendez FD, Capanu M, O'Reilly EM, et al (2010). Advanced hepatocellular carcinoma: which staging systems best predict prognosis? J Clin Oncol, 28, 2889-95. https://doi.org/10.1200/JCO.2009.25.9895
  14. Iasonos A, Schrag D, Raj GV, et al (2008). How to build and interpret a nomogram for cancer prognosis. J Clin Oncol, 26, 1364-70. https://doi.org/10.1200/JCO.2007.12.9791
  15. Kamura T, Tsukamoto N, Tsuruchi N, et al (1992). Multivariate analysis of the histopathologic prognostic factors of cervical cancer in patients undergoing radical hysterectomy. Cancer, 69, 181-6. https://doi.org/10.1002/1097-0142(19920101)69:1<181::AID-CNCR2820690130>3.0.CO;2-B
  16. Kang S, Nam BH, Park JY, et al (2012). Risk assessment tool for distant recurrence after platinum-based concurrent chemoradiation in patients with locally advanced cervical cancer: a Korean gynecologic oncology group study. J Clin Oncol, 30, 2369-74. https://doi.org/10.1200/JCO.2011.37.5923
  17. Landoni F, Maneo A, Colombo A, et al (1997). Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet, 350, 535-40. https://doi.org/10.1016/S0140-6736(97)02250-2
  18. Nguyen TL, Nguyen DC, Nguyen TH, et al (2011). Survey-based cancer mortality in the Lao PDR, 2007-08. Asian Pac J Cancer Prev, 12, 2495-8.
  19. Pecorelli S, Zigliani L, Odicino F (2009). Revised FIGO staging for carcinoma of the cervix. Int J Gynaecol Obstet, 105, 107-8. https://doi.org/10.1016/j.ijgo.2009.02.009
  20. Singh P, Tripcony L, Nicklin J (2012). Analysis of prognostic variables, development of predictive models, and stratification of risk groups in surgically treated FIGO early-stage (IA-IIA) carcinoma cervix. Int J Gynecol Cancer, 22, 115-22. https://doi.org/10.1097/IGC.0b013e31822fa8bb
  21. Small W, Jr., Strauss JB, Jhingran A, et al (2012). ACR appropriateness criteria(R) definitive therapy for early-stage cervical cancer. Am J Clin Oncol, 35, 399-405. https://doi.org/10.1097/COC.0b013e3182610537
  22. Sternberg CN (2006). Are nomograms better than currently available stage groupings for bladder cancer? J Clin Oncol, 24, 3819-20. https://doi.org/10.1200/JCO.2006.07.1290
  23. Tseng JY, Yen MS, Twu NF, et al (2010). Prognostic nomogram for overall survival in stage IIB-IVA cervical cancer patients treated with concurrent chemoradiotherapy. Am J Obstet Gynecol, 202, 174 e1-7. https://doi.org/10.1016/j.ajog.2009.09.028
  24. Waggoner SE (2003). Cervical cancer. Lancet, 361, 2217-25. https://doi.org/10.1016/S0140-6736(03)13778-6
  25. Walz J, Gallina A, Saad F, et al (2007). A nomogram predicting 10-year life expectancy in candidates for radical prostatectomy or radiotherapy for prostate cancer. J Clin Oncol, 25, 3576-81. https://doi.org/10.1200/JCO.2006.10.3820
  26. Wang Y, Li J, Xia Y, et al (2013). Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol, 31, 1188-95. https://doi.org/10.1200/JCO.2012.41.5984
  27. Williams NL, Werner TL, Jarboe EA, et al (2015). Adenocarcinoma of the cervix: should we treat it differently? Curr Oncol Rep, 17, 440.
  28. Yuan CC, Wang PH, Lai CR, et al (1998). Prognosis-predicting system based on factors related to survival of cervical carcinoma. Int J Gynaecol Obstet, 63, 163-7. https://doi.org/10.1016/S0020-7292(98)00142-8

피인용 문헌

  1. Prediction of 5–year overall survival in cervical cancer patients treated with radical hysterectomy using computational intelligence methods vol.17, pp.1, 2017, https://doi.org/10.1186/s12885-017-3806-3
  2. Nomogram Predicting Overall Survival in Operable Cervical Cancer Patients vol.27, pp.5, 2017, https://doi.org/10.1097/IGC.0000000000000987