Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Anti-Mycobacterial Activity of Tamoxifen Against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis

  • Jang, Woong Sik (Regional Innovation Center, Soonchunhyang University) ;
  • Kim, Sukyung (Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University) ;
  • Podder, Biswajit (Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University) ;
  • Jyoti, Md. Anirban (Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University) ;
  • Nam, Kung-Woo (Departments of Life Science and Biotechnology) ;
  • Lee, Byung-Eui (Chemistry, Soonchunhyang University) ;
  • Song, Ho-Yeon (Regional Innovation Center, Soonchunhyang University)
  • Received : 2014.12.10
  • Accepted : 2015.01.22
  • Published : 2015.06.28
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Abstract

Recently, it has become a struggle to treat tuberculosis with the current commercial antituberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We evaluated here the antimycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drugsensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had antituberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 µg/ml) as well as drugresistant strains (MIC, 6.25 to 12.5 µg/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.

Keywords

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