한국어병학회지 (Journal of fish pathology)

  • 제28권2호
  • /
  • Pages.93-98
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  • 2015
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  • 1226-0819(pISSN)
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  • 2233-5412(eISSN)
한국어병학회 (The Korean Society of Fish Pathology)
권호 표지
DOI QR코드

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Immunological significance of recombinant VP2 and VP3 proteins of aquabirnavirus in olive flounder, Paralichthys olivaceus

  • Kim, Hyoung Jun (National Fishery Products Quality Management Services) ;
  • Kim, Ki Hong (Department of Aquatic Life Medicine, Pukyong National University) ;
  • Park, Jeong Su (Department of Aquatic Life Medical Sciences, Sunmoon University) ;
  • Lee, Haeng Lim (Department of Aquatic Life Medical Sciences, Sunmoon University) ;
  • Kwon, Hyuk Chu (Department of Aquatic Life Medical Sciences, Sunmoon University) ;
  • Kwon, Se Ryun (Department of Aquatic Life Medical Sciences, Sunmoon University)
  • 투고 : 2014.12.05
  • 심사 : 2015.08.17
  • 발행 : 2015.08.30
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초록

Full-length recombinant VP2 and VP3 proteins of aquabirnavirus isolated from olive flounder were expressed successfully in E. coli expression system. After rats were immunized with these proteins, antisera were used for in vitro and in vivo neutralization test. In in vitro test, VP2 antibody titers were higher than that of VP3. In in vivo assays, fish challenged with aquabirnavirus neutralized with VP2 antibody survived longer than other fish.

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참고문헌

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