Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Beneficial Effects of Daebong Persimmon against Oxidative Stress, Inflammation, and Immunity in vivo

대봉감의 항산화, 항염증 및 면역증강 효과

  • Lee, Hee Jae (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Lim, So Young (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Kang, Min-Gyung (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Park, Jeongjin (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Chung, Hyun-Jung (Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University) ;
  • Yang, Soo Jin (Department of Food and Nutrition, Seoul Women's University)
  • 이희재 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 임소영 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 강민경 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 박정진 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 정현정 (전남대학교 식품영양과학부.생활과학연구소) ;
  • 양수진 (서울여자대학교 식품영양학과)
  • Received : 2014.12.05
  • Accepted : 2014.12.23
  • Published : 2015.04.30
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Abstract

The purpose of this study was to assess the antioxidant, anti-inflammatory, and immuno-enhancing effects of Daebong persimmon (DP) and Bansi (BS) in vivo. Two types of astringent persimmons (DP and BS) were used for this experiment. C57BL/6J mice were assigned to the following groups: 1) lean control, 2) high-fat diet control (HF), 3) A region DP (3% wt/wt) with HF diet (A-DP), 4) B region DP with HF diet (B-DP), 5) C region DP with HF diet (C-DP), 6) D region BS with HF diet (D-BS), and 7) E region BS with HF diet (E-BS). All mice were sacrificed after 4 weeks of treatment, after which blood and tissues were collected. Antioxidant enzyme activities, inflammatory markers, and immune factors were evaluated. DP and BS treatments did not alter food intake or body weight, compared with HF. Administration of B-DP increased catalase activities in serum. Hepatic levels of malondialdehyde, a product of lipid peroxidation, were significantly lower in A-DP mice than in the HF group. A-DP had down-regulatory effects against inflammation induced by high-fat diet feeding, as shown by significant reduction of interleukin (IL)-$1{\beta}$, IL-6, and tumor necrosis factor-${\alpha}$. Additionally, A-DP treatment exerted an immuno-stimulatory effect, as shown by increasing levels of immunoglobulin G. DP treatment improved the level of insulin-like growth factor-1. These results indicate that DP has beneficial health effects on oxidative stress, inflammation, and immunity in vivo.

본 연구는 대표적인 떫은 감 품종인 대봉감과 반시의 항산화, 항염증 및 면역증강 효과를 탐색, 비교하였다. 쥐 모델을 대상으로 4주간 대봉감과 반시의 섭취는 식이섭취량과 체중 변화에 영향을 미치지 않았다. B지역의 대봉감 섭취는 고지방식이 대조군 대비 유의적으로 카탈레이즈 활성 수준을 증가시켰으며, 간 조직의 지질과산화물인 말론디알데하이드 수준은 고지방식이 대조군 대비 A지역 대봉감을 섭취한 군에서 유의적으로 감소하였다. 또한 A지역 대봉감의 섭취는 염증인자인 IL-1 beta의 수준을 고지방식이군 대비 유의적으로 감소시켰다. 또 다른 대표적인 염증인자인 IL-6는 고지방식이 대조군과 비교하여 A지역과 B지역의 대봉감을 섭취한 군에서 유의적으로 감소시켰다. TNF-alpha 수준은 A지역의 대봉감을 섭취한 군에서 고지방식이대조군 대비 유의적으로 감소되었다. A지역 대봉감 섭취는 IgG의 수준을 고지방식이 대조군 대비 유의적으로 증가시켰다. IGF-1의 수준은 고지방식이 대조군과 비교하여 A, B, C 지역 대봉감 섭취군에서 증가하였다. 이상의 결과로부터 대봉감의 섭취는 우수한 항염증 효과와 면역증강 효과가 있을 것으로 사료된다.

Keywords

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