Journal of Nutrition and Health

  • 제48권2호
  • /
  • Pages.133-139
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  • 2015
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
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갱년기 모델 유도 흰 쥐에서 갈근과 지황 복합물 및 유산소 운동이 대사이상 개선에 미치는 영향

Effects of a Pueraria lobata-root based combination supplement containing Rehmannia glutinosa and aerobic exercise on improvement of metabolic dysfunctions in ovariectomized rats

  • 오상아 (이화여자대학교 식품영양학과) ;
  • 옥향목 (이화여자대학교 식품영양학과) ;
  • 김혜진 (이화여자대학교 체육과학과) ;
  • 이원준 (이화여자대학교 체육과학과) ;
  • 권오란 (이화여자대학교 식품영양학과)
  • Oh, Sang A (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Ok, Hyang Mok (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Kim, Hye Jin (Department of Exercise Science, College of Health Sciences, Ewha Womans University) ;
  • Lee, Won Jun (Department of Exercise Science, College of Health Sciences, Ewha Womans University) ;
  • Kwon, Oran (Department of Nutritional Science and Food Management, Ewha Womans University)
  • 투고 : 2014.12.03
  • 심사 : 2015.03.27
  • 발행 : 2015.04.30
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초록

본 연구는 갈근과 지황 복합물과 유산소 운동이 난소절제로 갱년기를 유도한 흰 쥐에서 나타나는 지질 및 당대사 이상에 미치는 영향을 확인하였다. 난소절제 후 8주간 AIN-76A 식이를 급여한 결과 체중증가량, 식이섭취량, 체 지방, 혈장 LDL-C, 공복혈당 증가를 통해 갱년기 동물 모델이 유도되었음을 확인할 수 있었다. 갈근과 지황 복합물과 유산소 운동은 서로 다른 기전으로 에스트로겐 분비 저하로 나타나는 비만 및 대사이상을 정상화하는 유익한 결과를 나타냈다. 지방 조직에서 확인된 관련 기전으로는 갈근과 지황 복합물로 인한 아디포넥틴 유전자 발현 증가 및 렙틴저항 억제, 유산소 운동으로 인한 아디포넥틴 및 인슐린 수용체 유전자 발현 증가, 갈근과 지황 복합물 및 유산소 운동의 병행으로 인한 아디포넥틴 유전자 발현 증가 상승효과가 관찰되었다. 이상의 결과로 갈근과 지황 복합물과 유산소 운동의 병행은 폐경기 에스트로겐 결핍으로 인한 대사이상을 개선하는 효과가 있을 것으로 기대한다. 향후에는 폐경기 유도 동물모델의 개선과 함께 단백질 및 신호전달분자 수준에서 추가적인 기전연구가 필요할 것으로 사료된다.

Purpose: There is a fair amount of evidence indicating that increased risk of obesity and insulin resistance is associated with postmenopausal state, but can be modulated by diet and exercise. In this study, we explored whether a Pueraria lobata root-based supplement containing Rehmannia glutinosa (PR) and/or aerobic treadmill exercise can modify the metabolic changes associated with estrogen deficiency. Methods: Seventy rats were randomly assigned to the following groups for 8 weeks (n=10 per group): SHAM, sham-operated; PR0, ovariectomized (OVX) control; PR200, OVX with PR200 mg/kg B.W; PR400, OVX with PR400 mg/kg B.W; EPR0, OVX with exercise; EPR200, OVX with exercise and PR200 mg/kg B.W; EPR400, OVX with exercise and PR400 mg/kg B.W. Results: OVX induced significant increases in body weight, food intake, fat mass, LDL-cholesterol, and fasting blood glucose, confirming induction of menopausal symptoms. PR supplementation or exercise significantly suppressed the above mentioned changes through different regulatory elements in adipose tissue: PR supplement upregulated adiponectin gene expression and aerobic exercise upregulated adiponectin and insulin receptor gene expression and a combination of PR supplement and aerobic exercise showed an additive effect on adiponectin gene expression. Conclusion: Taken together, the results of this study suggest that PR supplement has a potential to provide health benefits in OVX rats through leptin and adiponectin secretion. In addition, the data suggest that combination of exercise and PR would have additive effects on metabolic dysfunction associated with estrogen deficiency.

키워드

과제정보

연구 과제번호 : Research on New Functional Food Materials with Domestic Agricultural Products

연구 과제 주관 기관 : Rural Development Administration

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피인용 문헌

  1. , Prevents Postmenopausal Obesity in Ovariectomized Rats vol.2017, pp.1741-4288, 2017, https://doi.org/10.1155/2017/8641535