Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Effects of Fermented Extracts Zizyphus jujuba Fruits and Leaves Mixture on Hyperlipidemia in Rats Induced by High Fat Diet

대추과육과 대추잎 혼합발효추출물이 고지방식이로 유발된 고지혈증 흰쥐에 미치는 영향

  • Chong, MyongSoo (College of Oriental Medicine, Wonkwang University) ;
  • Cho, Hwaeun (Department of Agri-food Resource Development, Kunjang University College) ;
  • Kim, Heaja (Graduate School of Alternative Medicine, Kyonggi University) ;
  • Choi, YunHee (Department of Oriental Medicine & Healthcare, Wonkwang Digital University)
  • 정명수 (원광대학교 한의대학 예방의학교실) ;
  • 조화은 (군장대학교 농식품자원과) ;
  • 김혜자 (경기대학교 대체의학대학원) ;
  • 최윤희 (원광디지털대학교 한방건강학과)
  • Received : 2015.03.11
  • Accepted : 2015.04.12
  • Published : 2015.04.30
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Abstract

Objective : This study was designed to investigate the effects of non fermented Zizyphus. jujuba mixture (mixed fruit and leaf : ZM) and fermented Z. jujuba mixture(FZM) on fed high-fat diet induced hyperlipidemic rats for development medicinal food. Method : The extracts prepared for Zizyphus. jujuba mixture(ZM) and fermented Z. jujuba mixture(FZM) with Lactobacillus plantarum and Saccharomyces cerevisiae. Experimental group was divided into normal control group(NC group) and high fat diet groups. The high fat diet groups fed high fat diet 2 weeks after was sub-divided into high fat diet control group(HC group), high fat diet positive control group(HPC group), non fermented Z. jujuba mixture extract group(ZM group) and fermented Z. jujuba mixture extract group(FZM group). NC and HC group was orally administerd of 0.9% saline, HPC group administerd lovastatin diluted in 0.9% saline at a dose of 10 mg/kg BW, ZM and FZM groups was administerd each extracts diluted in 0.9% saline at a dose of 300 mg/kg BW once a day on a fixed time for 4 weeks. In the present study we measured organ weight, epididymal fat tissue weight, concentration of serum lipids, hepatic lipids, MDA contents in liver tissue and metabolic variables in serum. Results : ZM and FZM suppressed testis weight loss and FZM decreased epididymal fat tissue weight to level of NC group in high-fat diets. ZM and FZM did not influence on serum cholesterol level, but prominently decreased serum triglyceride concentration compared with HC group, and FZM diminished hepatic triglyceride same as serum. ZM and FZM did not impair liver and kidney function and influence positive effects through by suppression of elevation lipid level. Conclusion : These results suggested that Z. jujuba mixture(ZM, FZM) should be useful developing medicinal food for prevention and improvement of hyperlipidemia and FZM is more suitable agent than ZM.

Keywords

Acknowledgement

Supported by : 원광대학교

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