YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Concise Synthesis of Flurbiprofen via Palladium-Catalyzed Cross-Coupling Reactions

팔라듐 촉매하 결합반응을 이용한 플루비프로펜의 간결한 합성

  • Received : 2015.03.15
  • Accepted : 2015.04.14
  • Published : 2015.04.30
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Abstract

A concise synthesis of flurbiprofen, a member of the non-steroidal anti-inflammatory 2-arylpropionic acids, has been accomplished. The key feature of this synthesis involves successive palladium-catalyzed cross coupling reactions. In particular, a 2-arylacylate intermediate, which easily converted to the key 2-arylpropionic acid scaffold, was afforded by a versatile palladium-catalyzed cross coupling reaction between diazopropanate and bisphenylboronic acid. This synthetic procedure would facilitate synthesis of the flurbiprofen and anti-inflammatory 2-arylpropionic acid derivatives.

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References

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