YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and NF-κB Inhibitory Activities of N-Substituted-aryl-3-phenylpropanamide Derivatives

N-아릴-3-페닐프로판아마이드 유도체 합성 및 NF-κB 저해 활성

  • Choi, Minho (College of Pharmacy, Chungbuk National University) ;
  • Kim, Youngsoo (College of Pharmacy, Chungbuk National University) ;
  • Jung, Jae-Kyung (College of Pharmacy, Chungbuk National University) ;
  • Lee, Heesoon (College of Pharmacy, Chungbuk National University)
  • Received : 2015.02.12
  • Accepted : 2015.03.06
  • Published : 2015.04.30
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Abstract

A series of N-substitutedaryl-3-phenylpropanamide derivatives were synthesized and their inhibitory activities on LPS-induced NF-$1{\kappa}B$ transcriptional activity on RAW 264.7 cells were evaluated. Cl substituted derivatives (1e, 1f) have shown more potent activities than parent hit compound KL-1156.

Keywords

Acknowledgement

Supported by : 충북대학교

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