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Atypical β-Catenin Activated Child Hepatocellular Tumor

  • Turan, Aynur (Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital) ;
  • Unlu, Havva Akmaz (Department of Radiology, Ankara Pediatric Hematology and Oncology Training and Research Hospital) ;
  • Karakus, Esra (Department of Patology, Ankara Pediatric Hematology and Oncology Training and Research Hospital) ;
  • Erdem, Arzu Yazal (Department of Pediatrics, Ankara Pediatric Hematology and Oncology Training and Research Hospital) ;
  • Yakut, Zeynep Ilerisoy (Department of Radiology, Ankara Ataturk Training and Research Hospital)
  • Received : 2014.10.28
  • Accepted : 2015.01.31
  • Published : 2015.06.30

Abstract

Hepatocellular adenomas are a benign, focal, hepatic neoplasm that have been divided into four subtypes according to the genetic and pathological features. The ${\beta}$-catenin activated subtype accounts for 10-15% of all hepatocellular adenomas and specific magnetic resonance imaging features have been defined for different hepatocellular adenomas subtypes. The current study aimed to report the magnetic resonance imaging features of a well differentiated hepatocellular carcinoma that developed on the basis of ${\beta}$-catenin activated hepatocellular adenomas in a child. In this case, atypical diffuse steatosis was determined in the lesion. In the literature, diffuse steatosis, which is defined as a feature of the hepatocyte nuclear factor-$1{\alpha}$-inactivated hepatocellular adenomas subtype, has not been previously reported in any ${\beta}$-catenin activated hepatocellular adenomas case. Interlacing magnetic resonance imaging findings between subtypes show that there are still many mysteries about this topic and larger studies are warranted.

Keywords

References

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