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Rapidly Enlarging Pediatric Cortical Ependymoma

  • Yamasaki, Kouji (Department of Neurosurgery, Faculty of Medicine, University of Miyazaki) ;
  • Yokogami, Kiyotaka (Department of Neurosurgery, Faculty of Medicine, University of Miyazaki) ;
  • Yamashita, Shinji (Department of Neurosurgery, Faculty of Medicine, University of Miyazaki) ;
  • Takeshima, Hideo (Department of Neurosurgery, Faculty of Medicine, University of Miyazaki)
  • Received : 2014.03.17
  • Accepted : 2014.05.13
  • Published : 2015.06.28

Abstract

We report a 10-year-old boy with supratentorial cortical ependymoma that rapidly grew in the course of 3 years. He suffered generalized seizures when he was 5 years old; MRI showed a small cortical lesion in the right postcentral gyrus. MRI performed 2 years later revealed no changes. For the next 3 years he was free of seizures. However, at the age of 10 he again suffered generalized seizures and MRI disclosed a large parietal tumor. It was resected totally and he remains free of neurological deficits. The histopathological diagnosis was ependymoma. Pediatric supratentorial cortical ependymomas are extremely rare. We recommend including cortical ependymoma as a differential diagnosis in pediatric patients with cortical mass lesions presenting with seizures and careful follow-up even in the absence of symptoms because these tumors may progress.

Keywords

References

  1. Afra D, Muller W, Slowik F, Wilcke O, Budka H, Turoczy L : Supratentorial lobar ependymomas : reports on the grading and survival periods in 80 cases, including 46 recurrences. Acta Neurochir (Wien) 69 : 243-251, 1983 https://doi.org/10.1007/BF01401811
  2. Fujimoto K, Ohnishi H, Koshimae N, Ida Y, Kanemoto Y, Motoyama Y, et al. : [Brain surface clear cell ependymoma : case report]. No Shinkei Geka 27 : 843-846, 1999
  3. Ghani AR, Abdullah JM, Ghazali M, Ahmad F, Ahmad KA, Madhavan M : Recurrent paediatric supratentorial extraventricular ependymoma associated with genetic mutation at exon 4 of p53 gene. Singapore Med J 49 : e192-e194, 2008
  4. Grajkowska W, Matyja E, Pronicki M, Daszkiewicz P, Roszkowski M, Perek D, et al. : Papillary ependymoma with unique superficial cortical location : immunohistochemical and ultrastructural studies. A case report. Folia Neuropathol 47 : 354-361, 2009
  5. Hamano E, Tsutsumi S, Nonaka Y, Abe Y, Yasumoto Y, Saeki H : Huge supratentorial extraventricular anaplastic ependymoma presenting with massive calcification-case report. Neurol Med Chir (Tokyo) 50 : 150-153, 2010 https://doi.org/10.2176/nmc.50.150
  6. Hiniker A, Lee HS, Chang S, Berger M, Perry A : Cortical ependymoma with unusual histologic features. Clin Neuropathol 32 : 318-323, 2013 https://doi.org/10.5414/NP300593
  7. Lee SK, Lim DJ, Kim SD : Supratentorial cortical ependymoma in a 21-month-old boy. J Korean Neurosurg Soc 50 : 244-247, 2011 https://doi.org/10.3340/jkns.2011.50.3.244
  8. Lehman NL : Patterns of brain infiltration and secondary structure formation in supratentorial ependymal tumors. J Neuropathol Exp Neurol 67 : 900-910, 2008 https://doi.org/10.1097/NEN.0b013e31818521cd
  9. Lehman NL, Jorden MA, Huhn SL, Barnes PD, Nelson GB, Fisher PG, et al. : Cortical ependymoma. A case report and review. Pediatr Neurosurg 39 : 50-54, 2003 https://doi.org/10.1159/000070881
  10. Lellouch-Tubiana A, Boddaert N, Bourgeois M, Fohlen M, Jouvet A, Delalande O : Angiocentric neuroepithelial tumor (ANET) : a new epilepsy-related clinicopathological entity with distinctive MRI. Brain Pathol 15 : 281-286, 2005
  11. Liu Z, Li J, Liu Z, Wang Q, Famer P, Mehta A, et al. : Supratentorial cortical ependymoma : case series and review of the literature. Neuropathology 34 : 243-252, 2014 https://doi.org/10.1111/neup.12087
  12. Lum DJ, Halliday W, Watson M, Smith A, Law A : Cortical ependymoma or monomorphous angiocentric glioma? Neuropathology 28 : 81-86, 2008 https://doi.org/10.1111/j.1440-1789.2007.00831.x
  13. Massimino M, Buttarelli FR, Antonelli M, Gandola L, Modena P, Giangaspero F : Intracranial ependymoma : factors affecting outcome. Future Oncol 5 : 207-216, 2009 https://doi.org/10.2217/14796694.5.2.207
  14. Miyazawa T, Hirose T, Nakanishi K, Uozumi Y, Tsuzuki N, Shima K : Supratentorial ectopic cortical ependymoma occurring with intratumoral hemorrhage. Brain Tumor Pathol 24 : 35-40, 2007 https://doi.org/10.1007/s10014-007-0215-3
  15. Molina OM, Colina JL, Luzardo GD, Mendez OE, Cardozo D, Velasquez HS, et al. : Extraventricular cerebral anaplastic ependymomas. Surg Neurol 51 : 630-635, 1999 https://doi.org/10.1016/S0090-3019(98)00118-9
  16. Nakamizo S, Sasayama T, Kondoh T, Inoue S, Shiomi R, Tanaka H, et al. : Supratentorial pure cortical ependymoma. J Clin Neurosci 19 : 1453-1455, 2012 https://doi.org/10.1016/j.jocn.2011.09.039
  17. Ohwaki K, Tanishima T, Yoshimasu N, Hojo S, Fujimaki T, Kirino T : [Rapidly enlarging supratentorial ependymoma in a child presenting initially with a small calcified lesion : case report]. No Shinkei Geka 25 : 713-718, 1997
  18. Prayson RA : Tumours arising in the setting of paediatric chronic epilepsy. Pathology 42 : 426-431, 2010 https://doi.org/10.3109/00313025.2010.493870
  19. Preusser M, Hoischen A, Novak K, Czech T, Prayer D, Hainfellner JA, et al. : Angiocentric glioma : report of clinico-pathologic and genetic findings in 8 cases. Am J Surg Pathol 31 : 1709-1718, 2007 https://doi.org/10.1097/PAS.0b013e31804a7ebb
  20. Rigante L, Novello M, Massimi L, Caldarelli M : A cortical cystic epileptogenic lesion : tanycytic ependymoma. Acta Neurol Belg 113 : 523-525, 2013 https://doi.org/10.1007/s13760-012-0157-3
  21. Roncaroli F, Consales A, Fioravanti A, Cenacchi G : Supratentorial cortical ependymoma : report of three cases. Neurosurgery 57 : E192; discussion E192, 2005 https://doi.org/10.1227/01.NEU.0000164171.29292.D6
  22. Takeshima H, Kawahara T, Uchida H, Hirano H, Nakazato Y, Kuratsu J : Brain surface ependymoma with repeated episodes of intratumoral hemorrhage-case report. Neurol Med Chir (Tokyo) 42 : 166-169, 2002 https://doi.org/10.2176/nmc.42.166
  23. Van Gompel JJ, Koeller KK, Meyer FB, Marsh WR, Burger PC, Roncaroli F, et al. : Cortical ependymoma : an unusual epileptogenic lesion. J Neurosurg 114 : 1187-1194, 2011 https://doi.org/10.3171/2010.12.JNS10846
  24. Vernet O, Farmer JP, Meagher-Villemure K, Montes JL : Supratentorial ectopic ependymoma. Can J Neurol Sci 22 : 316-319, 1995 https://doi.org/10.1017/S0317167100039561
  25. Vinchon M, Soto-Ares G, Riffaud L, Ruchoux MM, Dhellemmes P : Supratentorial ependymoma in children. Pediatr Neurosurg 34 : 77-87, 2001 https://doi.org/10.1159/000055999
  26. Wang M, Tihan T, Rojiani AM, Bodhireddy SR, Prayson RA, Iacuone JJ, et al. : Monomorphous angiocentric glioma : a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. J Neuropathol Exp Neurol 64 : 875-881, 2005 https://doi.org/10.1097/01.jnen.0000182981.02355.10
  27. Yadav YR, Neha, Chandrakar SK : Pure cortical supratentorial extraventricular ependymoma. Neurol India 57 : 213-215, 2009 https://doi.org/10.4103/0028-3886.51301
  28. Yurt A, Selcuki M, Erturk AR, Kupelioglu A : Large supratentorial cortical ependymoma in a child. Clin Med Res 8 : 25-27, 2010 https://doi.org/10.3121/cmr.2010.877

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