Journal of Digestive Cancer Research

Korean Society of Gastrointestinal Cancer Research (대한소화기암연구학회)
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Current and New Molecularly Targeted Agents for Metastatic Gastric Cancer

  • Sung Chul Park (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kangwon National University School of Medicine)
  • Received : 2015.05.16
  • Accepted : 2015.06.20
  • Published : 2015.06.30
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Abstract

The discovery of HER2, a biomarker in advanced gastric cancer, and successful clinical trial using trastuzumab that targets this biomarker signaled a revolutionary turning point in treatment of metastatic gastric cancer. Many studies about targeted agents for gastric cancer have been attempted. Among them, ramicirumab, a monoclonal antibody that targets vascular endothelial growth factor receptor-2 (VEGFR-2), and apatinib, a tyrosine kinase inhibitor (TKI) that targets VEGFR2, have shown to improve the survival rates in advanced gastric cancer patients, for whom previous therapies had failed; hence, they are expected to be accepted as one of the standard therapies for advanced gastric cancer.

Keywords

References

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