Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Two Cases of Progressive Transformation of Germinal Centers(PTGC) in Head and Neck Area

두경부에 발생한 Progressive Transformation of Germinal Centers(PTGC) 환자 2예

  • Han, Won Gue (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University Ansan Hospital) ;
  • Kim, Tae Min (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University Ansan Hospital) ;
  • Yoon, Hee chul (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University Ansan Hospital) ;
  • Yum, Gun hwee (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University Ansan Hospital) ;
  • Oh, Kyoung Ho (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University Ansan Hospital) ;
  • Kwon, Soon Young (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University Ansan Hospital)
  • 한원규 (고려대학교 의과대학 안산병원 이비인후-두경부외과학교실) ;
  • 김태민 (고려대학교 의과대학 안산병원 이비인후-두경부외과학교실) ;
  • 윤희철 (고려대학교 의과대학 안산병원 이비인후-두경부외과학교실) ;
  • 염건휘 (고려대학교 의과대학 안산병원 이비인후-두경부외과학교실) ;
  • 오경호 (고려대학교 의과대학 안산병원 이비인후-두경부외과학교실) ;
  • 권순영 (고려대학교 의과대학 안산병원 이비인후-두경부외과학교실)
  • Received : 2015.03.27
  • Accepted : 2015.04.29
  • Published : 2015.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

Progressive transformation of germinal centers(PTGC) is a rare benign lymph node enlargement characterized by chronic lymphadenopathy and the presence of germinal centers with fused and expanded mantles within a lymph node that are 3-5 times the size of a typical reactive follicle. Although PTGC is reported in 3.5-10% of chronic lymphadenopathy, head and neck surgeons do not often experience this condition and its clinical implications. Althoug PTGC is benign disease, it could not be excluded the association with other malignant lymphoid diseases. Therefore, periodic follow up of PTGC patient could be required. We report two cases at this study ; a 16 years old man who visited out-patient clinic due to palpable mass of right cervical area, several months ago, and a 35 years old man who visited out-patient clinic for evaluating right cervical mass. Both of two patients were diagnosed with PTGC. In this study, we focus on the clinic-pathologic features of this uncommon disease along with other literature reviews.

Keywords

References

  1. Pollina L, PaciBiswas G, Das A, Haldar D, Mukherjee A, Dutta S, Sinha R, et al. Clinico-pathological correlates of cervical lymphadenopathy: A hospital based study. Indian journal of otolaryngology and head and neck surgery: Official publication of the Association of Otolaryngologists of India. 2013;65:42-47. https://doi.org/10.1007/s12070-011-0443-z
  2. Jeong WJ, Park MW, Park SJ, Ahn SH. Initial work-up for cervical lymphadenopathy: Back to basics. European archives of oto-rhino-laryngology: Official journal of the European Federation of Oto-Rhino-Laryngological Societies. 2012;269:2255-2263.
  3. Hansmann ML, Fellbaum C, Hui PK, Moubayed P. Progressive transformation of germinal centers with and without association to Hodgkin's disease. American Journal of Clinical Pathology. 1990;93:219-226. https://doi.org/10.1093/ajcp/93.2.219
  4. Li CM, Yang RF, Shen WY, Gong QX, Chen LJ, Xu W, et al. [Progressive transformation of lymph node germinal centers: A case report and literature review.]. Zhonghua Xue Ye Xue Za Zhi. 2010;31:253-256.
  5. Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC, et al. Progressive transformation of germinal centers. Report of 2 cases and review of the literature. ActaHaematol 2002;108:33-38.
  6. Hicks J, Flaitz C. Progressive transformation of germinal centers: Review of histopathologic and clinical features. International Journal of Pediatric Otorhinolaryngology. 2002;65:195-202. https://doi.org/10.1016/S0165-5876(02)00176-3
  7. Osborne BM, Butler JJ, Gresik MV. Progressive transformation of germinal centers: Comparison of 23 pediatric patients to the adult population. Mod Pathol. 1992;5:135-140.
  8. Kojima M, Nakamura S, Motoori T, Itoh H, Shimizu K, Yamane N, et al. Progressive transformation of germinal centers: A clinicopathological study of 42 Japanese patients. Int J Surg Pathol. 2003;11(2):101-107. https://doi.org/10.1177/106689690301100205
  9. Nguyen PL, Ferry JA, Harris NL. Progressive transformation of germinal centers and nodular lymphocyte predominance Hodgkin's disease: A Comparative immunohistochemical study. Am J Surg Pathol. 1999;23:27-33. https://doi.org/10.1097/00000478-199901000-00003
  10. Poppema S, Kaiserling E, Lennert K. Nodular paragranuloma and progressively transformed germinal centers. Ultrastructural and immunohistologic findings. Virchows Arch B Cell Pathol Incl Mol Pathol. 1979;31:211-225. https://doi.org/10.1007/BF02889938
  11. Burns BF, Colby TV, Dorfman RF. Differential diagnostic features of nodular L & H Hodgkin's disease, including progressive transformation of germinal centers. The American Journal of Surgical Pathology. 1984;8:253-261. https://doi.org/10.1097/00000478-198404000-00002
  12. Sweetenham JW, Polliack A. Progressive transformation of germinal centers and Hodgkin lymphoma: More insights but maybe more confusion? Leukemia & Lymphoma. 2011;52:2041-2042. https://doi.org/10.3109/10428194.2011.614710