Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Neuroglial Cells : An Overview of Their Physiological Roles and Abnormalities in Mental Disorders

신경아교세포의 정상 기능과 정신장애에서 나타나는 신경아교세포 이상에 대한 고찰

  • Lee, Kyungmin (Laboratory for Behavioral Neural Circuit and Physiology, Department of Anatomy, Graduate School of Medicine, Kyungpook National University)
  • 이경민 (경북대학교 의학전문대학원 해부학교실)
  • Received : 2015.03.16
  • Accepted : 2015.05.15
  • Published : 2015.05.31
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Abstract

The brain maintains homeostasis and normal microenvironment through dynamic interactions of neurons and neuroglial cells to perform the proper information processing and normal cognitive functions. Recent post-mortem investigations and animal model studies demonstrated that the various brain areas such as cerebral cortex, hippocampus and amygdala have abnormalities in neuroglial numbers and functions in subjects with mental illnesses including schizophrenia, dementia and mood disorders like major depression and bipolar disorder. These findings highlight the putative role and involvement of neuroglial cells in mental disorders. Herein I discuss the physiological roles of neuroglial cells such as astrocytes, oligodendrocytes, and microglia in maintaining normal brain functions and their abnormalities in relation to mental disorders. Finally, all these findings could serve as a useful starting point for potential therapeutic concept and drug development to cure unnatural behaviors and abnormal cognitive functions observed in mental disorders.

Keywords

References

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