참고문헌
- Abrahamsen, H., Stenmark, H., and Platta, H.W. (2012). Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression. FEBS Lett. 586, 1584-1591. https://doi.org/10.1016/j.febslet.2012.04.046
- Alcalay, R.N., Caccappolo, E., Mejia-Santana, H., Tang, M.X., Rosado, L., Ross, B.M., Verbitsky, M., Kisselev, S., Louis, E.D., Comella, C., et al. (2010). Frequency of known mutations in early- onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study. Arch. Neurol. 67, 1116-1122.
- Alegre-Abarrategui, J., Christian, H., Lufino, M.M., Mutihac, R., Venda, L.L., Ansorge, O., and Wade-Martins, R. (2009). LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 18, 4022-4034. https://doi.org/10.1093/hmg/ddp346
- Andersen, P.M., and Al-Chalabi, A. (2011). Clinical genetics of amyotrophic lateral sclerosis: what do we really know? Nat. Rev. Neurol. 7, 603-615. https://doi.org/10.1038/nrneurol.2011.150
- Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M.T., Michel, P.P., Marquez, J., Mouatt-Prigent, A., Ruberg, M., Hirsch, E.C., and Agid, Y. (1997). Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol. Histopathol. 12, 25-31.
- Barmada, S.J., Serio, A., Arjun, A., Bilican, B., Daub, A., Ando, D.M., Tsvetkov, A., Pleiss, M., Li, X., Peisach, D., et al. (2014). Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat. Chem. Biol. 10, 677-685. https://doi.org/10.1038/nchembio.1563
- Bonifati, V. (2006). Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics. Eur. J. Hum. Genet. 14, 1061-1062. https://doi.org/10.1038/sj.ejhg.5201695
- Boya, P., Reggiori, F., and Codogno, P. (2013). Emerging regulation and functions of autophagy. Nat. Cell Biol. 15, 713-720. https://doi.org/10.1038/ncb2788
- Burli, R.W., Luckhurst, C.A., Aziz, O., Matthews, K.L., Yates, D., Lyons, K.A., Beconi, M., McAllister, G., Breccia, P., Stott, A.J., et al. (2013). Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. J. Med. Chem. 56, 9934-9954. https://doi.org/10.1021/jm4011884
- Caccamo, A., Majumder, S., Richardson, A., Strong, R., and Oddo, S. (2010). Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J. Biol. Chem. 285, 13107-13120. https://doi.org/10.1074/jbc.M110.100420
- Chen, D., Fan, W., Lu, Y., Ding, X., Chen, S., and Zhong, Q. (2012). A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol. Cell. 45, 629-641. https://doi.org/10.1016/j.molcel.2011.12.036
- Cherra, S.J. 3rd, and Chu, C.T. (2008). Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurol. 3, 309-323.
- Ching, J.K., and Weihl, C.C. (2013). Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCPassociated myopathy. Autophagy 9, 799-800. https://doi.org/10.4161/auto.23958
- Cortes, C.J, and La Spada, A.R. (2014). The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. Drug Discov. Today 19, 963-971. https://doi.org/10.1016/j.drudis.2014.02.014
- Coune, P.G., Bensadoun, J.C., Aebischer, P., and Schneider, B.L. (2011). Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alphasynuclein based rat model of Parkinson's disease. J. Parkinsons Dis. 1, 373-387.
- Crippa, V., Sau, D., Rusmini, P., Boncoraglio, A., Onesto, E., Bolzoni, E., Galbiati, M., Fontana ,E., Marino, M., Carra, S., et al. (2010). The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Hum. Mol. Genet. 19, 3440-3456. https://doi.org/10.1093/hmg/ddq257
-
Decressac, M., Mattsson, B., Weikop, P., Lundblad, M., Jakobsson, J., and Bjorklund, A. (2013). TFEB-mediated autophagy rescues midbrain dopamine neurons from
$\alpha$ -synuclein toxicity. Proc. Natl. Acad. Sci. USA 110, E1817-1826. https://doi.org/10.1073/pnas.1305623110 - Deng, Y.N., Shi, J., Liu, J., and Qu, Q.M. (2013). Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy. Neurochem. Int. 63, 1-9. https://doi.org/10.1016/j.neuint.2013.04.005
- Dolan, P.J., and Johnson, G.V. (2010). A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. J. Biol. Chem. 285, 21978-21987. https://doi.org/10.1074/jbc.M110.110940
- Du, G., Liu, X., Chen, X., Song, M., Yan, Y., Jiao, R., and Wang, C.C. (2010). Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation. Mol. Biol. Cell 21, 2128-2137. https://doi.org/10.1091/mbc.E10-03-0200
- Duyao, M.P., Auerbach, A.B., Ryan, A., Persichetti, F., Barnes, G.T., McNeil, S.M., Ge, P., Vonsattel, J.P., Gusella, J.F., Joyner, A.L., et al. (1995). Inactivation of the mouse Huntington's disease gene homolog Hdh. Science 269, 407-410. https://doi.org/10.1126/science.7618107
-
Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B.T., McLean, P.J., and Unni, V.K. (2011). Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of
$\alpha$ - synuclein. J. Neurosci. 31, 14508-14520. https://doi.org/10.1523/JNEUROSCI.1560-11.2011 - Filimonenko, M., Isakson, P., Finley, K.D., Anderson, M., Jeong, H., Melia, T.J., Bartlett, B.J., Myers, K.M., Birkeland, H.C., Lamark, T. et al. (2010). The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol. Cell 38, 265-279. https://doi.org/10.1016/j.molcel.2010.04.007
- Filomeni, G., Graziani, I., De Zio, D., Dini, L., Centonze, D., Rotilio, G., and Ciriolo, M.R. (2012). Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease. Neurobiol. Aging 33, 767-785. https://doi.org/10.1016/j.neurobiolaging.2010.05.021
- Forlenza, O.V., de Paula, V.J., Machado-Vieira, R., Diniz, B.S., and Gattaz, W.F. (2012). Does lithium prevent Alzheimer's disease? Drugs Aging 29, 335-342. https://doi.org/10.2165/11599180-000000000-00000
- Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca, M.L., Lazzeri, G., Spalloni, A., Bellio, N., Lenzi, P., et al. (2008). Lithium delays progression of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 105, 2052-2057. https://doi.org/10.1073/pnas.0708022105
- Gamblin, T.C., Chen, F., Zambrano, A., Abraha, A., Lagalwar, S., Guillozet, A.L., Lu, M., Fu, Y., Garcia-Sierra, F., LaPointe, N., et al. (2003). Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 100, 10032-10037. https://doi.org/10.1073/pnas.1630428100
- Giordano, S., Darley-Usmar, V., and Zhang, J. (2014). Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biol. 2, 82-90. https://doi.org/10.1016/j.redox.2013.12.013
- Hadano, S., Otomo, A., Kunita, R., Suzuki-Utsunomiya, K., Akatsuka, A., Koike, M., Aoki, M., Uchiyama, Y., Itoyama, Y., and Ikeda, J.E. (2010). Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS One 5, e9805. https://doi.org/10.1371/journal.pone.0009805
- Hamano, T., Gendron, T.F., Causevic, E., Yen, S.H., Lin, W.L., Isidoro, C., Deture, M., and Ko, L.W. (2008). Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression. Eur. J. Neurosci. 27, 1119-1130. https://doi.org/10.1111/j.1460-9568.2008.06084.x
- Han, H., Wei, W., Duan, W., Guo, Y., Li, Y., Wang, J., Bi, Y., and Li, C. (2014). Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). In Vitro Cell. Dev. Biol. Anim. [Epub ahead of print]
- Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A.M., Brown, R.H., and Glimcher, L.H. (2009). XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev. 23, 2294-2306. https://doi.org/10.1101/gad.1830709
- Hyttinen, J.M., Niittykoski, M., Salminen, A., and Kaarniranta, K. (2013). Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim. Biophys. Acta 1833, 503-510. https://doi.org/10.1016/j.bbamcr.2012.11.018
- Jaeger, P.A., Pickford, F., Sun, C.H., Lucin, K.M., Masliah, E., and Wyss-Coray, T. (2010). Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS One 5, e11102. https://doi.org/10.1371/journal.pone.0011102
- Jia, H., Kast, R.J., Steffan, J.S., and Thomas, E.A. (2012). Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitinproteasomal and autophagy systems. Hum. Mol. Genet. 21, 5280-5293. https://doi.org/10.1093/hmg/dds379
-
Jiang, T.F., Zhang, Y.J., Zhou, H.Y., Wang, H.M., Tian, L.P., Liu, J., Ding, J.Q., and Chen, S.D. (2013). Curcumin ameliorates the neurodegenerative pathology in A53T
$\alpha$ -synuclein cell model of Parkinson's disease through the downregulation of mTOR/ p70S6K signaling and the recovery of macroautophagy. J. Neuroimmune Pharmacol. 8, 356-669. https://doi.org/10.1007/s11481-012-9431-7 - Juenemann, K., Schipper-Krom, S., Wiemhoefer, A., Kloss, A., Sanz Sanz, A., and Reits, E.A. (2013). Expanded polyglutaminecontaining N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes. J. Biol. Chem. 288, 27068-27084. https://doi.org/10.1074/jbc.M113.486076
- Kaushik, S., and Cuervo, A.M. (2012). Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 22, 407-417. https://doi.org/10.1016/j.tcb.2012.05.006
- Kesidou, E., Lagoudaki, R., Touloumi, O., Poulatsidou, K.N., and Simeonidou, C. (2013). Autophagy and neurodegenerative disorders. Neural Regen. Res. 8, 2275-2283.
- Kickstein, E., Krauss, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., Köhler, A., Glossmann, H., et al. (2010). Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc. Natl. Acad. Sci. USA 107, 21830-21835. https://doi.org/10.1073/pnas.0912793107
- Kiernan, M.C., Vucic, S., Cheah, B.C., Turner, M.R., Eisen, A., Hardiman, O., Burrell, J.R., and Zoing, M.C. (2011). Amyotrophic lateral sclerosis. Lancet 377, 942-955. https://doi.org/10.1016/S0140-6736(10)61156-7
- Koga, H., Martinez-Vicente, M., Arias, E., Kaushik, S., Sulzer, D., and Cuervo, A.M. (2011). Constitutive upregulation of chaperone- mediated autophagy in Huntington's disease. J. Neurosci. 31, 18492-18505. https://doi.org/10.1523/JNEUROSCI.3219-11.2011
- Komatsu, M., and Ichimura, Y. (2010). Selective autophagy regulates various cellular functions. Genes Cells 15, 923-933. https://doi.org/10.1111/j.1365-2443.2010.01433.x
- Lee, J.A. (2012). Neuronal autophagy: a housekeeper or a fighter in neuronal cell survival? Exp. Neurobiol. 21, 1-8. https://doi.org/10.5607/en.2012.21.1.1
- Lee, J.H., Yu, W.H., Kumar, A., Lee, S., Mohan, P.S., Peterhoff, C.M., Wolfe, D.M., Martinez-Vicente, M., Massey, A.C., Sovak, G., et al. (2010). Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141, 1146-1158. https://doi.org/10.1016/j.cell.2010.05.008
- Li, L., Zhang, X., and Le, W. (2008). Altered macroautophagy in the spinal cord of SOD1 mutant mice. Autophagy 4, 290-293. https://doi.org/10.4161/auto.5524
- Li, W.W., Li, J., and Bao, J.K. (2012). Microautophagy: lesserknown self-eating. Cell. Mol. Life Sci. 69, 1125-1136. https://doi.org/10.1007/s00018-011-0865-5
- Lin, T.K., Chen, S.D., Chuang, Y.C., Lin, H.Y., Huang, C.R., Chuang, J.H., Wang, P.W., Huang, S.T., Tiao, M.M., Chen, J.B., et al. (2014). Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy. Int. J. Mol. Sci. 15, 1625-1646. https://doi.org/10.3390/ijms15011625
- Liu, D., Pitta, M., Jiang, H., Lee, J.H., Zhang, G., Chen, X., Kawamoto, E.M., and Mattson, M.P. (2013). Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession. Neurobiol. Aging 34, 1564-1580. https://doi.org/10.1016/j.neurobiolaging.2012.11.020
- Lucin, K.M., O'Brien, C.E., Bieri, G., Czirr, E., Mosher, .KI., Abbey, R.J., Mastroeni, D.F., Rogers, J., Spencer, B., Masliah, E., et al. (2013). Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 79, 873-886. https://doi.org/10.1016/j.neuron.2013.06.046
- Manzoni, C., Mamais, A., Dihanich, S., Abeti, R., Soutar, M.P., Plun- Favreau, H., Giunti, P., Tooze, S.A., Bandopadhyay, R., and Lewis, P.A. (2013). Inhibition of LRRK2 kinase activity stimulates macroautophagy. Biochim. Biophys. Acta 1833, 2900-2910. https://doi.org/10.1016/j.bbamcr.2013.07.020
- Martin, D.D., Ladha, S., Ehrnhoefer, D.E., and Hayden, M.R. (2015). Autophagy in Huntington disease and huntingtin in autophagy. Trends Neurosci. 38, 26-35. https://doi.org/10.1016/j.tins.2014.09.003
- Martinez-Vicente, M., Talloczy, Z., Kaushik, S., Massey, A.C., Mazzulli, J., Mosharov, E.V., Hodara, R., Fredenburg R., Wu, D.C., Follenzi, A., et al. (2008). Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118, 777-788.
- Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D., et al. (2010). Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat. Neurosci. 13, 567-576. https://doi.org/10.1038/nn.2528
- Millecamps, S., and Julien, J.P. (2013). Axonal transport deficits and neurodegenerative diseases. Nat. Rev. Neurosci. 14, 161-176. https://doi.org/10.1038/nrn3380
- Mizushima, N., Yoshimori, T., and Ohsumi, Y. (2011). The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 27, 107-132. https://doi.org/10.1146/annurev-cellbio-092910-154005
- Mizushima, N. (2010). The role of the Atg1/ULK1 complex in autophagy regulation. Curr. Opin. Cell Biol. 22, 132-139. https://doi.org/10.1016/j.ceb.2009.12.004
- Morimoto, N., Nagai, M., Ohta, Y., Miyazaki, K., Kurata, T., Morimoto, M., Murakami, T., Takehisa, Y., Ikeda, Y., Kamiya, T., et al. (2007). Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res. 1167, 112-117. https://doi.org/10.1016/j.brainres.2007.06.045
- Nagata, E., Sawa, A., Ross, C.A., and Snyder, SH. (2004). Autophagosome-like vacuole formation in Huntington's disease lymphoblasts. Neuroreport 15, 1325-1328. https://doi.org/10.1097/01.wnr.0000127073.66692.8f
-
Nah, J., Pyo, J.O., Jung, S., Yoo, S.M., Kam, T.I., Chang, J., Han, J., Soo A An, S., Onodera, T., and Jung, Y.K. (2013). BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid
$\beta$ 42. Autophagy 9, 2009-2021. https://doi.org/10.4161/auto.26118 - Nair, U., Jotwani, A., Geng, J., Gammoh, N., Richerson, D., Yen, W.L., Griffith, J., Nag, S., Wang, K., Moss, T., et al. (2011). SNARE proteins are required for macroautophagy. Cell 146, 290-302. https://doi.org/10.1016/j.cell.2011.06.022
- Nakatogawa, H., Suzuki, K., Kamada, Y., and Ohsumi, Y. (2009). Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat. Rev. Mol. Cell Biol. 10, 458-467. https://doi.org/10.1038/nrm2708
- Narendra, D., Tanaka, A., Suen, D.F., and Youle, R.J. (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803. https://doi.org/10.1083/jcb.200809125
- Nassif, M., Valenzuela, V., Rojas-Rivera, D., Vidal, R., Matus, S., Castillo, K., Fuentealba, Y., Kroemer, G., Levine, B., and Hetz, C. (2014). Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis. Autophagy 10, 1256-1271. https://doi.org/10.4161/auto.28784
- Nixon, R.A., Wegiel, J., Kumar, A., Yu, W.H., Peterhoff, C., Cataldo, A., and Cuervo, A.M. (2005). Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 64, 113-122. https://doi.org/10.1093/jnen/64.2.113
- Orenstein, S.J., Kuo, S.H., Tasset, I., Arias, E., Koga, H., Fernandez- Carasa, I., Cortes, E., Honig, L.S., Dauer, W., Consiglio, A., et al. (2013). Interplay of LRRK2 with chaperone-mediated autophagy. Nat. Neurosci. 16, 394-406. https://doi.org/10.1038/nn.3350
- Pan, P.Y., and Yue, Z. (2014). Genetic causes of Parkinson's disease and their links to autophagy regulation. Parkinsonism Relat. Disord. 20 Suppl 1, S154-157. https://doi.org/10.1016/S1353-8020(13)70037-3
- Pandey, U.B., Nie, Z., Batlevi, Y., McCray, B.A., Ritson, G.P., Nedelsky, N.B., Schwartz, S.L., DiProspero, N.A., Knight, M.A., Schuldiner, O., et al. (2007). HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863.
- Pickford, F., Masliah, E., Britschgi, M., Lucin, K., Narasimhan, R., Jaeger, P.A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008). The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Invest. 118, 2190-2199.
- Pizzasegola, C., Caron, I., Daleno, C., Ronchi, A., Minoia, C., Carrì, M.T., and Bendotti, C. (2009). Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice. Amyotroph. Lateral Scler. 10, 221-228. https://doi.org/10.1080/17482960902803440
- Qi, L., and Zhang, X.D. (2014). Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein. Acta Biochim. Biophys. Sin. (Shanghai) 46, 83-91. https://doi.org/10.1093/abbs/gmt133
- Querfurth, H.W., and LaFerla, F.M. (2010). Alzheimer's disease. N. Engl. J. Med. 362, 329-344. https://doi.org/10.1056/NEJMra0909142
- Ravikumar, B., Vacher, C., Berger, Z., Davies, J.E., Luo, S., Oroz, L.G., Scaravilli, F., Easton, D.F., Duden, R., O'Kane, C.J., et al. (2004). Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36, 585-595. https://doi.org/10.1038/ng1362
- Rodriguez-Martín, T., Cuchillo-Ibanez, I., Noble, W., Nyenya, F., Anderton, B.H., and Hanger, D.P. (2013). Tau phosphorylation affects its axonal transport and degradation. Neurobiol. Aging 34, 2146-2157. https://doi.org/10.1016/j.neurobiolaging.2013.03.015
- Rohn, T.T., Wirawan, E., Brown, R.J., Harris, J.R., Masliah, E., and Vandenabeele, P. (2011). Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain. Neurobiol. Dis. 43, 68-78. https://doi.org/10.1016/j.nbd.2010.11.003
- Rose, C., Menzies, F.M., Renna, M., Acevedo-Arozena, A., Corrochano, S., Sadiq, O., Brown, S.D., and Rubinsztein, D.C. (2010). Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum. Mol. Genet. 19, 2144-2153. https://doi.org/10.1093/hmg/ddq093
- Russell, R.C., Tian, Y., Yuan, H., Park, H.W., Chang, Y.Y., Kim, J., Kim, H., Neufeld, T.P., Dillin, A., and Guan, K.L. (2013). ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 15, 741-750. https://doi.org/10.1038/ncb2757
- Sala, G., Stefanoni, G., Arosio, A., Riva, C., Melchionda, L., Saracchi, E., Fermi, S., Brighina, L., and Ferrarese, C. (2014). Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease. Brain Res. 1546, 46-52. https://doi.org/10.1016/j.brainres.2013.12.017
- Sasaki, S. (2011). Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 70, 349-359. https://doi.org/10.1097/NEN.0b013e3182160690
- Scarffe, L.A., Stevens, D.A., Dawson, V.L., and Dawson, T.M. (2014). Parkin and PINK1: much more than mitophagy. Trends Neurosci. 37, 315-324. https://doi.org/10.1016/j.tins.2014.03.004
- Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B., and Yuan, J. (2006). Regulation of intracellular accumulation of mutant Huntingtin by Beclin1. J. Biol. Chem. 281, 14474-14485. https://doi.org/10.1074/jbc.M600364200
- Shibutani, S.T., and Yoshimori, T. (2014) A current perspective of autophagosome biogenesis. Cell Res. 24, 58-68. https://doi.org/10.1038/cr.2013.159
- Shintani, T., and Klionsky, D.J. (2004). utophagy in health and disease: a double-edged sword. Science 306, 990-995. https://doi.org/10.1126/science.1099993
- Shoji-Kawata, S., Sumpter, R., Leveno, M., Campbell, G.R., Zou, Z., Kinch, L., Wilkins, A.D., Sun, Q., Pallauf, K., MacDuff, D., et al. (2013). Identification of a candidate therapeutic autophagyinducing peptide. Nature 494, 201-206. https://doi.org/10.1038/nature11866
- Shpilka, T., Mizushima, N., and Elazar, Z. (2012). Ubiquitin-like proteins and autophagy at a glance. J. Cell Sci. 125, 2343-2348. https://doi.org/10.1242/jcs.093757
-
Son, S.M., Jung, E.S., Shin, H.J., Byun, J., and Mook-Jung, I. (2012).
$A{\beta}$ -induced formation of autophagosomes is mediated by RAGE-$CaMKK{\beta}$ -AMPK signaling. Neurobiol. Aging 33, 1006.e11-23. - Song, C.Y., Guo, J.F., Liu, Y., and Tang, B.S. (2012). Autophagy and Its Comprehensive Impact on ALS. Int. J. Neurosci. 122, 695-703. https://doi.org/10.3109/00207454.2012.714430
- Spencer, B., Potkar, R., Trejo, M., Rockenstein, E., Patrick, C., Gindi, R., Adame, A., Wyss-Coray, T., and Masliah, E. (2009). Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J. Neurosci. 29, 13578-13588. https://doi.org/10.1523/JNEUROSCI.4390-09.2009
- Staats, K.A., Hernandez, S., Schönefeldt, S., Bento-Abreu, A., Dooley, J., Van Damme P., Liston, A., Robberecht, W., and Van Den Bosch, L. (2013). Rapamycin increases survival in ALS mice lacking mature lymphocytes. Mol. Neurodegener 8, 31. https://doi.org/10.1186/1750-1326-8-31
-
Steele, J.W., and Gandy, S. (2013). Latrepirdine (Dimebon
$^{(R)}$ ), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy 9, 617-618. https://doi.org/10.4161/auto.23487 - Surendran, S., and Rajasankar, S. (2010). Parkinson's disease: oxidative stress and therapeutic approaches. Neurol. Sci. 31, 531-540. https://doi.org/10.1007/s10072-010-0245-1
- Tan, C.C., Yu, J.T., Tan, M.S., Jiang, T., Zhu, X.C., and Tan, L. (2014). Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy. Neurobiol. Aging 35, 941-957. https://doi.org/10.1016/j.neurobiolaging.2013.11.019
- Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N.R., Doi, H., Kurosawa, M., Nekooki, M., and Nukina, N. (2004). Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat. Med. 10, 148-154. https://doi.org/10.1038/nm985
- Thompson, L,M., Aiken, C,T., Kaltenbach, L.S., Agrawal, N., Illes, K., Khoshnan, A., Martinez-Vincente, M., Arrasate, M., O'Rourke, J.G., Khashwji, H., et al. (2009). IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J. Cell Biol. 187, 1083-1099. https://doi.org/10.1083/jcb.200909067
- Tian, Y., Bustos, V., Flajolet, M., and Greengard, P. (2011). A smallmolecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 25, 1934-1942. https://doi.org/10.1096/fj.10-175158
- Tsvetkov, A.S., Miller, J., Arrasate, M., Wong, J.S., Pleiss, M.A., and Finkbeiner, S. (2010). A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. Proc. Natl. Acad. Sci. USA. 107, 16982-16987. https://doi.org/10.1073/pnas.1004498107
- Ulamek-Kozio, M., Furmaga-Jablonska, W., Januszewski, S., Brzozowska, J., Scislewska, M., Jablonski, M., and Pluta, R. (2013). Neuronal autophagy: self-eating or self-cannibalism in Alzheimer's disease. Neurochem. Res. 38, 1769-1773. https://doi.org/10.1007/s11064-013-1082-4
- Vingtdeux, V., Giliberto, L., Zhao, H., Chandakkar, P., Wu, Q., Simon, J.E., Janle, E.M., Lobo, J., Ferruzzi. M.G., Davies. P., et al. (2010). AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J. Biol. Chem. 285, 9100-9113. https://doi.org/10.1074/jbc.M109.060061
- Wacker, J.L., Zareie, M.H., Fong, H., Sarikaya, M., and Muchowski, P.J. (2004). Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer. Nat. Struct. Mol. Biol. 11, 1215-1222. https://doi.org/10.1038/nsmb860
- Waldemar, G., Dubois, B., Emre, M., Georges, J., McKeith, I.G., Rossor, M., Scheltens, P., Tariska, P., and Winblad, B. (2007). Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline. Eur. J. Neurol. 14, e1-26.
- Wang, J.Z., Xia, Y.Y., Grundke-Iqbal, I., and Iqbal, K. (2013). Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. J. Alzheimers Dis. 33 Suppl 1, S123-139.
- Weidberg, H., Shvets, E., and Elazar, Z. (2011). Biogenesis and cargo selectivity of autophagosomes. Annu. Rev. Biochem. 80, 125-156. https://doi.org/10.1146/annurev-biochem-052709-094552
- Yu, W.H., Cuervo, A.M., Kumar, A., Peterhoff, C.M., Schmidt, S.D., Lee, J.H., Mohan, P.S., Mercken, M., Farmery, M.R., Tjernberg, L.O., et al. (2005). Macroautophagy--a novel Beta-amyloid peptide- generating pathway activated in Alzheimer's disease. J. Cell Biol. 171, 87-98. https://doi.org/10.1083/jcb.200505082
- Zhang, X., Li, L., Chen, S., Yang, D., Wang, Y., Zhang, X., Wang, Z., and Le, W. (2011). Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy 7, 412-425. https://doi.org/10.4161/auto.7.4.14541
- Zhang ,X., Chen, S., Song, L., Tang, Y., Shen, Y., Jia, L., and Le, W. (2014). MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. Autophagy 10, 588-602. https://doi.org/10.4161/auto.27710
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- Mitophagy in neurodegenerative diseases 2017, https://doi.org/10.1016/j.neuint.2017.08.004
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