Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Recovery Effect of Flavonoids from Morus alba Fruits on Alloxan-induced Pancreatic Islet in Zebrafish (Dinio rerio)

오디 Flavonoid의 alloxan 처리 zebrafish 췌장섬에 대한 회복효과

  • Seo, Kyeong-Hwa (Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung Hee University) ;
  • Nam, Youn-Hee (Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung Hee University) ;
  • Kim, Young-Eon (Korea Food Research Institute) ;
  • Hong, Eock-Kee (School of Biotechnology and Bioengineering, Kangwon National University) ;
  • Hong, Bin-Na (Department of Audiology, Nambu University) ;
  • Kang, Tong-Ho (Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung Hee University) ;
  • Baek, Nam-In (Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung Hee University)
  • Received : 2014.09.15
  • Accepted : 2014.11.19
  • Published : 2015.03.31
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Abstract

Flavonoids from Morus alba fruits were evaluated for recovery effect on the damage of alloxan-induced pancreatic islet in zebrafish. Alloxan treatment on the zebrafish embryo surely decreased the pancreatic islet size (p <0.001). Rutin, isoquercetin, and quercetin very significantly recovered the size (p <0.001) and the fluorescence intensity of pancreatic islet.

오디에서 분리한 flavonoid가 zebrafish에 alloxan을 처리하여 손상된 췌장섬을 어느 정도 회복 시키는지 검토하였다. Zebrafish의 배아에 alloxan을 처리하면 확실하게 췌장섬의 크기가 감소하였다(p <0.001). Rutin, isoquercetin 및 quercetin의 처리에 의해 췌장섬의 크기가 유의적으로 증가하였으며(p <0.001), 형광세포의 fluorescence intensity도 뚜렷하게 증가하였다.

Keywords

References

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