Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Relief Effect of Medicinal Herb Mixture HAE Series on Respiratory Symptoms

호흡기 증상에 대한 복합제 HAE의 완화 효과

  • Chang, Bo Yoon (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Da Eun (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Han, Ji Hye (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Lee, Joo Seok (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Dae Sung (HanpoongPharm. CO., Ltd.) ;
  • Cho, Hyoung Kwon (HanpoongPharm. CO., Ltd.) ;
  • Kim, Sung Yeon (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
  • 장보윤 (원광대학교 약학대학, 약품 연구소) ;
  • 김다은 (원광대학교 약학대학, 약품 연구소) ;
  • 한지혜 (원광대학교 약학대학, 약품 연구소) ;
  • 이주석 (원광대학교 약학대학, 약품 연구소) ;
  • 김대성 (한풍제약) ;
  • 조형권 (한풍제약) ;
  • 김성연 (원광대학교 약학대학, 약품 연구소)
  • Received : 2015.10.19
  • Accepted : 2015.11.10
  • Published : 2015.12.31
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Abstract

HAE series (HAE 01 - 06), are the mixtures of medicinal plants; Lonicerae Folium et Caulis (Lonicera japonica), Scutellariae Radix (Scutellaria baicalensis), Adenophorae Radix (Adenophora triphylla var. japonica), Polygonati Oddorati Rhizoma (Polygonatum odoratum var. pluriflorum), Platycodi Radix (Platycodon grandiflorum), Liriopis seu Ophiopogonis Tuber (Liriope platyphylla). HAE 06 showed the significant antitussive effect in HAE series. HAE 04, 05, and 06 increased the effect of expectorant measured by secretion of phenol red in rats. All tested HAE series were observed to have the anti-oxidant activity determined by the scavenging activity. HAE 01, 03 and 06 were significantly reduced the production of nitric oxide (NO) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) increased by LPS. HAE 06 was selected based on the results and done further experiments. HAE 06 inhibited the number of coughing induced by citric acid in dose dependent manner. HAE 06 effectively increased the effect of expectorant. HAE 06 exhibited anti-inflammatory effects by inhibiting the production of NO and TNF-${\alpha}$. In addition, HAE 06 significantly suppressed inducible Cyclooxygenase-2 (COX-2). Especially HAE 06 has the highest effect in alleviating the respiratory symptoms. Moreover, the enhancement antioxidant activity and reduction inflammation partly were attributed to it. HAE 06 may become the promising candidate for the treatment of respiratory symptom in the future.

Keywords

References

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