Biomaterials and Biomechanics in Bioengineering

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Topology effects on the LCST of end-capped poly(ethylene glycol)s

  • Kim, Jin Young (Department of Chemistry and Nano Science, Ewha Womans University) ;
  • Moon, Hyo Jung (Department of Chemistry and Nano Science, Ewha Womans University) ;
  • Ko, Du Young (Department of Chemistry and Nano Science, Ewha Womans University) ;
  • Jeong, Byeongmoon (Department of Chemistry and Nano Science, Ewha Womans University)
  • Received : 2015.01.28
  • Accepted : 2015.03.08
  • Published : 2015.03.25
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Abstract

Poly(ethylene glycol) end-capped with pentafluorophenyl group(s) in ABA (FP-PEG-FP) and AB (mPEG-FP) types were prepared. Even though they were similar in composition, the lower critical solution temperature (LCST) of FP-PEG-FP was observed at $23^{\circ}C$, whereas that of mPEG-FP was observed at $65^{\circ}C$. To understand the large difference in solution behaviour of the two polymers, UV-VIS spectroscopy, microcalorimetry, 1H-NMR spectroscopy, and dynamic light scattering were used. FP-PEG-FP has two hydrophobic pentafluorophenyl groups at the ends of hydrophilic PEG (1000 Daltons), whereas mPEG-PF has a highly dynamic PEG (550 Daltons) block that are anchored to a hydrophobic pentafluorophenyl group. PF-PEG-PF not only has a smaller conformational degree of freedom than mPEG-PF but also can form extensive intermolecular aggregates, therefore, PF-PEG-PF exhibits a significantly lower LCST than mPEG-PF. This paper suggests that topological control is very important in designing a temperature-sensitive polymer.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea

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