The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Biological Activities of Wild Sparassis crispa Extracts

야생 꽃송이버섯 추출물의 생리활성

  • Kim, Eun-Jung (Department of Biomedical Laboratory Science, Sangji University) ;
  • Yoo, Kwan-Hee (Department of Life Science, Sangji University) ;
  • Kim, Yang-Sup (Sejong Institute of Data Analysis Co Ltd.) ;
  • Seok, Soon-Ja (Agricultural Microbiology Division, National Academy of Agricultural Science, RDA) ;
  • Kim, Jun-Ho (Department of Fine Chemistry and New Materials, Sangji University)
  • 김은정 (상지대학교 임상병리학과) ;
  • 유관희 (상지대학교 생명과학과) ;
  • 김양섭 (세종데이터해석연구원) ;
  • 석순자 (국립농업과학원 농업미생물과) ;
  • 김준호 (상지대학교 정밀화학 신소재학과)
  • Received : 2015.02.20
  • Accepted : 2015.03.05
  • Published : 2015.03.31
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Abstract

Physiological activities of solvent extracts of Sparassis crispa were investigated for fibrinolytic, thrombin inhibitory, anti-oxidative and anti-inflammatory activities. The fibrinolytic activity was the highest in ethyl acetate extract (2.03 plasmin units/mL) followed by butanol extract (0.70 plasmin units/mL). The ethyl acetate extract exhibited the highest anti-oxidative activity as assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging rate with a value of 95.94%. The chloroform extract showed thrombin inhibitory activity up to 83.87%. The chloroform extract also showed the highest anti-inflammatory effects on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. These findings suggest that Sparassis crispa may be a useful material for development of drugs and functional foods.

야생 꽃송이버섯의 생리활성 물질을 탐색하여 기능성 식품 개발에 이용하기 위해 꽃송이버섯 물 추출물과 유기용매 분획물의 혈전 용해 활성과 트롬빈 저해 활성, 항산화 활성 및 항염증 활성을 확인하였다. 부탄올 분획물과 에틸아세테이트 분획물이 각각 0.70 plasmin unit과 2.03 plasmin unit의 높은 혈전 용해 활성을 나타내고, 클로로포름 분획물이 83.87%의 높은 트롬빈 저해 활성을 나타냈으며, 에틸아세테이트 분획물이 95.94%의 높은 항산화 활성을 나타냈으며, 클로로포름 분획물은 82.62%의 높은 항염증 활성을 나타냈다. 그러므로 본 연구에서 나타난 꽃송이버섯의 혈전 용해, 트롬빈 저해, 항산화 및 항염증 효과들의 우수한 생리활성 결과들로부터 꽃송이버섯은 혈관계 질환 성인병 치료와 예방을 위한 기능성 식품소재로 활용 가치가 매우 큼을 알 수 있었다.

Keywords

References

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