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Plasma Bioscience and Medicines

플라즈마 바이오과학 및 의학

  • 최은하 (광운대학교 전자물리학과 대전입자빔 및 플라즈마 연구실)
  • Published : 2015.12.30
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Abstract

Nonthermal bio-compatible plasma (bioplasma) sources and their characteristics operating at atmospheric pressure could be used for biological cell interactions, especially for plasma bioscience and medicines. The electron temperatures and plasma densities of this bioplasma are measured to be 0.7 ~ 1.8 eV and $(3-5){\times}10^{14-15}cm^{-3}$, respectively. Herein, we introduced general schematic view of the plasma-initiated ultraviolet photolysis of water inside the biological solutions or living tissue for the essential generation mechanism of the reactive hydroxyl radical [OH] and hydrogen peroxide [$H_2O_2$], which may result in apoptotic cell death in plasma bioscience and medicines. Further, we surveyed the various nonthermal bioplasma sources including plasma jet, micro-DBD (dielectric barrier discharge) and nanosecond discharged plasma. The diseased biological protein, cancer, and mutated cells could be treated by these bioplasma sources or bioplasma activated water to result in their apoptosis for new paradigm of plasma bioscience and medicines.

Keywords

References

  1. P. Attri, Y. H. Kim, D. H. Park, J. H. Park, Y. J. Hong, H. S. Uhm, K. N. Kim, A. Fridman, and E. H. Choi, "Generation mechanism of hydroxyl radical species and its lifetime prediction during the plasma-initiated ultraviolet plsama photolysis", Sci. Rep. 5, 9332 (2015). https://doi.org/10.1038/srep09332
  2. G. Kong, G. Kroesen, G. Morfill, T. Nosenko, T. Shimizu, J. V. Dijk, J. L. Zimmermann, "Plasma medicine: An introductory review", New J. Phys. 115012:1-115012:35 (2009).
  3. Trachootham et. al., "Targeting cancer cells by ROS-mediated mechanisms: a radical therapheutic approach?", Nat. Drug Discovery 8, 579-591 (2009). https://doi.org/10.1038/nrd2803
  4. N. Kaushik, N. Uddin, G. Bo Sim, Y. J. Hong, K. Y. Baik, C. H. Kim, S. J. Lee, N. K. Kaushik and E. H. Choi, "Responses of Solid Tumor Cells in DMEM to Reactive Oxygen Species Generated by Non-Thermal Plasma and Chemically Induced ROS Systems", Sci. Rep. 5, 8587 (2015). https://doi.org/10.1038/srep08587
  5. Y. Kim, S. Jin, G. H. Han, G. C. Kwon, J. J. Choi, E. H. Choi, H. S. Uhm, G. Cho, "Plasma Apparatuses for Biomedical Applications", IEEE TPS-43, 944 (2015).
  6. P. Attri, J. H. Park, J. Gaur, N. Kumar, D. H. Park, S. N. Jeon, B. S. Park, S. Chan, H. S. Uhm, E. H. Choi, "Influence of nanosecond pulsed plasma on the non-enzymatic pathway for the generation of nitric oxide from L-arginine and the modification of graphite oxide to increase the solar cell efficiency", Physical Chemistry Chemical Physics. 16(34). DOI: 10.1039/C4CP02514H (2014).
  7. S. A. Nathoo, "The chemistry and mechanisms of extrinsic and intrinsic discoloration", J. Am. Dent. Assoc. 128 Suppl:6S-10S, 1997. https://doi.org/10.14219/jada.archive.1997.0428
  8. 최은하,김경남,김용희,권재성, "플라즈마를 이용한 치아미백 방법 및 그 에 따른 플라즈마칫솔, 등록번호 10-1459952 (2014).

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  1. Plasma Bioscience and Medicines vol.30, pp.5, 2015, https://doi.org/10.5757/asct.2021.30.5.118