Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
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Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies

  • Byun, June-Ho (Department of Oral and Maxillofacial Surgery, Institute of Health Sciences, Gyeongsang National University School of Medicine) ;
  • Lee, Han A Reum (Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University) ;
  • Kim, Tae Ho (Department of Advanced Materials, Hannam University) ;
  • Lee, Jin Ho (Department of Advanced Materials, Hannam University) ;
  • Oh, Se Heang (Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University)
  • Received : 2014.07.18
  • Accepted : 2014.10.19
  • Published : 2015.03.31
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Abstract

Background: For the effective bone regeneration with appropriate pathological/physiological properties, a variety of bone fillers have been adapted as a therapeutic treatment. However, the development of ideal bone fillers is still remained as a big challenge in clinical practice. The main aims of this study are i) fabrication of a highly porous PCL beads; and ii) the estimation of the potential use of the porous PCL beads as a bone filler through preliminary animal study. Results: The porous PCL beads with size range of $53{\sim}600{\mu}m$ ($425{\sim}500{\mu}m$ dominantly) are fabricated by a spray/precipitation method using a double nozzle spray and PCL solution (in tetraglycol). The PCL beads show highly porous inner pore structure and the pores are interconnected with outer surface pores. For the preliminary animal study, we recognize that the porous PCL bead can induce the new bone formation from the outer surface of bone defect toward the bone marrow cavity through the bead matrix. Conclusions: From the preliminary results, we can suggest that the highly porous PCL beads may be a promising candidate as a bone filler (scaffolding matrix) for the effective bone regeneration.

Keywords

Acknowledgement

Supported by : Korea Health Industry Development Institute (KHIDI)

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