Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of the Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) Following Isoniazid Treatment

  • Lee, Jin-Yong (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Seol, Yun-Jae (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Shin, Dong-Woo (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Kim, Dae-Young (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Chun, Hong-Woo (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Kim, Bo-Young (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Jeong, Shin-Ok (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Lim, Sang-Hyok (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Jang, An-Soo (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital)
  • Received : 2014.08.04
  • Accepted : 2014.10.10
  • Published : 2015.01.30
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Abstract

The drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a severe adverse drug-induced reaction which includes a severe skin eruption, fever, hematologic abnormalities (eosinophilia or atypical lymphocytes) and internal organ involvement. The most frequently reported drug was anticonvulsants. The diagnosis of DRESS syndrome is challenging because the pattern of cutaneous eruption and the types of organs involved are various. The treatments for DRESS syndrome are culprit drug withdrawal and corticosteroids. Here we report a 71-year-old man with skin eruption with eosinophilia and hepatic and renal involvement that appeared 4 weeks after he had taken anti-tuberculosis drugs (isoniazid, ethambutol, rifampicin, and pyrazinamide), and resolved after stopping anti-tuberculosis drugs and the administration of systemic corticosteroids. DRESS recurred after re-challenging isoniazid, we identified isoniazid was causative drug.

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References

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