IMMUNE NETWORK

  • 제15권1호
  • /
  • Pages.16-26
  • /
  • 2015
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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DOI QR코드

DOI QR Code

Immune Cells in the Female Reproductive Tract

  • Lee, Sung Ki (Department of Obstetrics and Gynecology, College of Medicine, Konyang University) ;
  • Kim, Chul Jung (Department of Obstetrics and Gynecology, College of Medicine, Konyang University) ;
  • Kim, Dong-Jae (Department of Obstetrics and Gynecology, College of Medicine, Konyang University) ;
  • Kang, Jee-Hyun (Department of Family Medicine, College of Medicine, Konyang University)
  • 투고 : 2014.12.06
  • 심사 : 2015.01.28
  • 발행 : 2015.02.28
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⟨ 이전 논문 다음 논문 ⟩

초록

The female reproductive tract has two main functions: protection against microbial challenge and maintenance of pregnancy to term. The upper reproductive tract comprises the fallopian tubes and the uterus, including the endocervix, and the lower tract consists of the ectocervix and the vagina. Immune cells residing in the reproductive tract play contradictory roles: they maintain immunity against vaginal pathogens in the lower tract and establish immune tolerance for sperm and an embryo/fetus in the upper tract. The immune system is significantly influenced by sex steroid hormones, although leukocytes in the reproductive tract lack receptors for estrogen and progesterone. The leukocytes in the reproductive tract are distributed in either an aggregated or a dispersed form in the epithelial layer, lamina propria, and stroma. Even though immune cells are differentially distributed in each organ of the reproductive tract, the predominant immune cells are T cells, macrophages/dendritic cells, natural killer (NK) cells, neutrophils, and mast cells. B cells are rare in the female reproductive tract. NK cells in the endometrium significantly expand in the late secretory phase and further increase their number during early pregnancy. It is evident that NK cells and regulatory T (Treg) cells are extremely important in decidual angiogenesis, trophoblast migration, and immune tolerance during pregnancy. Dysregulation of endometrial/decidual immune cells is strongly related to infertility, miscarriage, and other obstetric complications. Understanding the immune system of the female reproductive tract will significantly contribute to women's health and to success in pregnancy.

키워드

참고문헌

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