Journal of Korean Neurosurgical Society

  • 제57권2호
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  • Pages.82-87
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  • 2015
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
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Impaired Voluntary Wheel Running Behavior in the Unilateral 6-Hydroxydopamine Rat Model of Parkinson's Disease

  • Pan, Qi (Department of Neurosurgery, Zhujiang Hospital, Southern Medical University) ;
  • Zhang, Wangming (Department of Neurosurgery, Zhujiang Hospital, Southern Medical University) ;
  • Wang, Jinyan (Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences) ;
  • Luo, Fei (Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences) ;
  • Chang, Jingyu (Neuroscience Research Institute of North Carolina) ;
  • Xu, Ruxiang (Department of Neurosurgery, Zhujiang Hospital, Southern Medical University)
  • 투고 : 2014.05.15
  • 심사 : 2014.08.01
  • 발행 : 2015.02.28
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초록

Objective : The aim of this study was to investigate voluntary wheel running behavior in the unilateral 6-hydroxydopamine (6-OHDA) rat model. Methods : Male Sprague-Dawley rats were assigned to 2 groups : 6-OHDA group (n=17) and control group (n=8). The unilateral 6-OHDA rat model was induced by injection of 6-OHDA into unilateral medial forebrain bundle using a stereotaxic instrument. Voluntary wheel running activity was assessed per day in successfully lesioned rats (n=10) and control rats. Each behavioral test lasted an hour. The following parameters were investigated during behavioral tests : the number of running bouts, the distance moved in the wheel, average peak speed in running bouts and average duration from the running start to the peak speed. Results : The number of running bouts and the distance moved in the wheel were significantly decreased in successfully lesioned rats compared with control rats. In addition, average peak speed in running bouts was decreased, and average duration from the running start to the peak speed was increased in lesioned animals, which might indicate motor deficits in these rats. These behavioral changes were still observed 42 days after lesion. Conclusion : Voluntary wheel running behavior is impaired in the unilateral 6-OHDA rat model and may represent a useful tool to quantify motor deficits in this model.

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참고문헌

  1. Belke TW, Wagner JP : The reinforcing property and the rewarding aftereffect of wheel running in rats : a combination of two paradigms. Behav Processes 68 : 165-172, 2005 https://doi.org/10.1016/j.beproc.2004.12.006
  2. Bove J, Perier C : Neurotoxin-based models of Parkinson's disease. Neuroscience 211 : 51-76, 2012 https://doi.org/10.1016/j.neuroscience.2011.10.057
  3. Bromberg-Martin ES, Matsumoto M, Hikosaka O. Dopamine in motivational control : rewarding, aversive, and alerting. Neuron 68 : 815-834, 2010 https://doi.org/10.1016/j.neuron.2010.11.022
  4. Carman LS, Gage FH, Shults CW : Partial lesion of the substantia nigra : relation between extent of lesion and rotational behavior. Brain Res 553 : 275-283, 1991 https://doi.org/10.1016/0006-8993(91)90835-J
  5. Cenci MA, Whishaw IQ, Schallert T : Animal models of neurological deficits : how relevant is the rat? Nat Rev Neurosci 3 : 574-579, 2002 https://doi.org/10.1038/nrn877
  6. Chang JY, Shi LH, Luo F, Woodward DJ : High frequency stimulation of the subthalamic nucleus improves treadmill locomotion in unilateral 6-hydroxydopamine lesioned rats. Brain Res 983 : 174-184, 2003 https://doi.org/10.1016/S0006-8993(03)03053-1
  7. Chang JY, Shi LH, Luo F, Zhang WM, Woodward DJ : Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease. Neurosci Biobehav Rev 32 : 352-366, 2008 https://doi.org/10.1016/j.neubiorev.2007.09.002
  8. da Conceicao FS, Ngo-Abdalla S, Houzel JC, Rehen SK : Murine model for Parkinson's disease : from 6-OH dopamine lesion to behavioral test. J Vis Exp (35) : 1376, 2010. http://dx.doi.org/10.3791/1376
  9. Deumens R, Blokland A, Prickaerts J : Modeling Parkinson's disease in rats : an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Exp Neurol 175 : 303-317, 2002 https://doi.org/10.1006/exnr.2002.7891
  10. Fornaguera J, Schwarting RK : Early behavioral changes after nigro-striatal system damage can serve as predictors of striatal dopamine depletion. Prog Neuropsychopharmacol Biol Psychiatry 23 : 1353-1368, 1999 https://doi.org/10.1016/S0278-5846(99)00071-8
  11. Galvan A, Wichmann T : Pathophysiology of parkinsonism. Clin Neurophysiol 119 : 1459-1474, 2008 https://doi.org/10.1016/j.clinph.2008.03.017
  12. Inden M, Taira T, Kitamura Y, Yanagida T, Tsuchiya D, Takata K, et al. : PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiol Dis 24 : 144-158, 2006 https://doi.org/10.1016/j.nbd.2006.06.004
  13. Ito C, Onodera K, Sakurai E, Sato M, Watanabe T : Effect of cocaine on the histaminergic neuron system in the rat brain. J Neurochem 69 : 875-878, 1997
  14. Iversen SD, Iversen LL : Dopamine : 50 years in perspective. Trends Neurosci 30 : 188-193, 2007 https://doi.org/10.1016/j.tins.2007.03.002
  15. Kasahara T, Kubota M, Miyauchi T, Noda Y, Mouri A, Nabeshima T, et al. : Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol Psychiatry 11 : 577-593, 523, 2006 https://doi.org/10.1038/sj.mp.4001824
  16. Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH, et al. : Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain 136 (Pt 8) : 2419-2431, 2013 https://doi.org/10.1093/brain/awt192
  17. Lau YS, Fung YK : Pharmacological effects of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) on striatal dopamine receptor system. Brain Res 369 : 311-315, 1986 https://doi.org/10.1016/0006-8993(86)90541-X
  18. Leng A, Mura A, Hengerer B, Feldon J, Ferger B : Effects of blocking the dopamine biosynthesis and of neurotoxic dopamine depletion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on voluntary wheel running in mice. Behav Brain Res 154 : 375-383, 2004 https://doi.org/10.1016/j.bbr.2004.03.004
  19. Liebetanz D, Baier PC, Paulus W, Meuer K, Bahr M, Weishaupt JH : A highly sensitive automated complex running wheel test to detect latent motor deficits in the mouse MPTP model of Parkinson's disease. Exp Neurol 205 : 207-213, 2007 https://doi.org/10.1016/j.expneurol.2007.01.030
  20. Meijer JH, Robbers Y : Wheel running in the wild. Proc Biol Sci 281 : 20140210, 2014. http://dx.doi.org/10.1098/rspb.2014.0210
  21. Nakata Y, Yasuda T, Mochizuki H : Recent progress in gene therapy for Parkinson's disease. Curr Mol Med 12 : 1311-1318, 2012 https://doi.org/10.2174/156652412803833580
  22. Niu C, Mei J, Pan Q, Fu X : Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition. Stereotact Funct Neurosurg 87 : 69-81, 2009 https://doi.org/10.1159/000202972
  23. Paxinos G, Watson C : The Rat Brain in Stereotaxic Coordinates, ed 6. New York : Academic Press, 2007
  24. Reglodi D, Lubics A, Tamas A, Szalontay L, Lengvari I : Pituitary adenylate cyclase activating polypeptide protects dopaminergic neurons and improves behavioral deficits in a rat model of Parkinson's disease. Behav Brain Res 151 : 303-312, 2004 https://doi.org/10.1016/j.bbr.2003.09.007
  25. Rhodes JS, Gammie SC, Garland T Jr : Neurobiology of Mice Selected for High Voluntary Wheel-running Activity. Integr Comp Biol 45 : 438-455, 2005 https://doi.org/10.1093/icb/45.3.438
  26. Rosenwasser AM, Clark JW, Fixaris MC, Belanger GV, Foster JA : Effects of repeated light-dark phase shifts on voluntary ethanol and water intake in male and female Fischer and Lewis rats. Alcohol 44 : 229-237, 2010 https://doi.org/10.1016/j.alcohol.2010.03.002
  27. Rosenwasser AM, Fixaris MC : Chronobiology of alcohol : studies in C57BL/6J and DBA/2J inbred mice. Physiol Behav 110-111 : 140-147, 2013 https://doi.org/10.1016/j.physbeh.2013.01.001
  28. Sherwin CM : Voluntary wheel running : a review and novel interpretation. Anim Behav 56 : 11-27, 1998 https://doi.org/10.1006/anbe.1998.0836
  29. Simola N, Morelli M, Carta AR. The 6-hydroxydopamine model of Parkinson's disease. Neurotox Res 11 : 151-167, 2007 https://doi.org/10.1007/BF03033565
  30. Ungerstedt U : Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand Suppl 367 : 69-93, 1971
  31. Weihmuller FB, Bruno JP, Neff NH, Hadjiconstantinou M : Dopamine receptor plasticity following MPTP-induced nigrostriatal lesions in the mouse. Eur J Pharmacol 180 : 369-372, 1990 https://doi.org/10.1016/0014-2999(90)90324-Y
  32. Wise RA : Dopamine, learning and motivation. Nat Rev Neurosci 5 : 483-494, 2004

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