Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma : A Preliminary Study

  • Park, Seong-Hyun (Department of Neurosurgery, Kyungpook National University Hospital) ;
  • Hwang, Jeong-Hyun (Department of Neurosurgery, Kyungpook National University Hospital) ;
  • Hwang, Sung-Kyoo (Department of Neurosurgery, Kyungpook National University Hospital)
  • Received : 2014.05.08
  • Accepted : 2014.09.26
  • Published : 2015.02.28
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Abstract

Objective : The purpose of this study was to investigate changes in the plasma level of vascular endothelial growth factor (VEGF) after Gamma Knife radiosurgery (GKRS) for the treatment of meningioma. Methods : Fourteen patients with meningiomas had peripheral venous blood collected at the time of GKRS and at 1 week, 1 month, 3 month and 6 month visits. Plasma VEGF levels were measured using commercially available enzyme-linked immunosorbent assay. For controls, peripheral blood samples were obtained from 20 healthy volunteers. Results : The mean plasma VEGF level (29.6 pg/mL) in patients with meningiomas before GKRS was significantly lower than that of the control group (62.4 pg/mL, p=0.019). At 1 week after GKRS, the mean plasma VEGF levels decreased to 23.4 pg/mL, and dropped to 13.9 pg/mL at 1 month, 14.8 pg/mL at 3 months, then increased to 27.7 pg/mL at 6 months. Two patients (14.3%) with peritumoral edema (PTE) showed a level of VEGF 6 months after GKRS higher than their preradiosurgical level. There was no significant association found in an analysis of correlation between PTE and tumor size, marginal dose, age, and sex. Conclusion : Our study is first in demonstrating changes of plasma VEGF after stereotactic radiosurgery (SRS) for meningioma. This study may provide a stimulus for more work related to whether measurement of plasma level has a correlation with tumor response after SRS for meningioma.

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References

  1. Chang JH, Chang JW, Choi JY, Park YG, Chung SS : Complications after gamma knife radiosurgery for benign meningiomas. J Neurol Neurosurg Psychiatry 74 : 226-230, 2003 https://doi.org/10.1136/jnnp.74.2.226
  2. Ganz JC, Schrottner O, Pendl G : Radiation-induced edema after Gamma Knife treatment for meningiomas. Stereotact Funct Neurosurg 66 Suppl 1 : 129-133, 1996 https://doi.org/10.1159/000099778
  3. Ilhan A, Gartner W, Neziri D, Czech T, Base W, Horl WH, et al. : Angiogenic factors in plasma of brain tumour patients. Anticancer Res 29 : 731-736, 2009
  4. Kan P, Liu JK, Wendland MM, Shrieve D, Jensen RL : Peritumoral edema after stereotactic radiosurgery for intracranial meningiomas and molecular factors that predict its development. J Neurooncol 83 : 33-38, 2007 https://doi.org/10.1007/s11060-006-9294-y
  5. Kim GH, Hahn DK, Kellner CP, Hickman ZL, Komotar RJ, Starke RM, et al. : Plasma levels of vascular endothelial growth factor after treatment for cerebral arteriovenous malformations. Stroke 39 : 2274-2279, 2008 https://doi.org/10.1161/STROKEAHA.107.512442
  6. Klatte T, Bohm M, Nelius T, Filleur S, Reiher F, Allhoff EP : Evaluation of peri-operative peripheral and renal venous levels of pro- and anti-angiogenic factors and their relevance in patients with renal cell carcinoma. BJU Int 100 : 209-214, 2007 https://doi.org/10.1111/j.1464-410X.2007.06871.x
  7. Kondziolka D, Flickinger JC, Perez B : Judicious resection and/or radiosurgery for parasagittal meningiomas : outcomes from a multicenter review. Gamma Knife Meningioma Study Group. Neurosurgery 43 : 405- 413; discussion 413-414, 1998 https://doi.org/10.1097/00006123-199809000-00001
  8. Kondziolka D, Levy EI, Niranjan A, Flickinger JC, Lunsford LD : Longterm outcomes after meningioma radiosurgery : physician and patient perspectives. J Neurosurg 91 : 44-50, 1999 https://doi.org/10.3171/jns.1999.91.1.0044
  9. Kraft A, Weindel K, Ochs A, Marth C, Zmija J, Schumacher P, et al. : Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease. Cancer 85 : 178-187, 1999 https://doi.org/10.1002/(SICI)1097-0142(19990101)85:1<178::AID-CNCR25>3.0.CO;2-7
  10. Nakamura S, Hiyama H, Arai K, Nakaya K, Sato H, Hayashi M, et al. : Gamma Knife radiosurgery for meningiomas : four cases of radiationinduced edema. Stereotact Funct Neurosurg 66 Suppl 1 : 142-145, 1996 https://doi.org/10.1159/000099804
  11. Novotny J Jr, Kollova A, Liscak R : Prediction of intracranial edema after radiosurgery of meningiomas. J Neurosurg 105 Suppl : 120-126, 2006
  12. Poon RT, Ng IO, Lau C, Zhu LX, Yu WC, Lo CM, et al. : Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma : a prospective study. Ann Surg 233 : 227-235, 2001 https://doi.org/10.1097/00000658-200102000-00012
  13. Preusser M, Hassler M, Birner P, Rudas M, Acker T, Plate KH, et al. : Microvascularization and expression of VEGF and its receptors in recurring meningiomas : pathobiological data in favor of anti-angiogenic therapy approaches. Clin Neuropathol 31 : 352-360, 2012 https://doi.org/10.5414/NP300488
  14. Schmid S, Aboul-Enein F, Pfisterer W, Birkner T, Stadek C, Knosp E : Vascular endothelial growth factor : the major factor for tumor neovascularization and edema formation in meningioma patients. Neurosurgery 67 : 1703-1708; discussion 1708, 2010 https://doi.org/10.1227/NEU.0b013e3181fb801b
  15. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF : Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219 : 983-985, 1983 https://doi.org/10.1126/science.6823562
  16. Torres RC, Frighetto L, De Salles AA, Goss B, Medin P, Solberg T, et al. : Radiosurgery and stereotactic radiotherapy for intracranial meningiomas. Neurosurg Focus 14 : e5, 2003
  17. Vermeulen S, Young R, Li F, Meier R, Raisis J, Klein S, et al. : A comparison of single fraction radiosurgery tumor control and toxicity in the treatment of basal and nonbasal meningiomas. Stereotact Funct Neurosurg 72 Suppl 1 : 60-66, 1999 https://doi.org/10.1159/000056440
  18. Yamamoto Y, Toi M, Kondo S, Matsumoto T, Suzuki H, Kitamura M, et al. : Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. Clin Cancer Res 2 : 821-826, 1996

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