한국섬유공학회지 (Textile Science and Engineering)

  • 제52권1호
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  • Pages.53-58
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  • 2015
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  • 1225-1089(pISSN)
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  • 2288-6419(eISSN)
한국섬유공학회 (The Korean Fiber Society)
권호 표지
DOI QR코드

DOI QR Code

Poly(L-lactic acid-block-γ-aminobutyric acid)의 합성과 특성

Synthesis and Characteristics of Poly(L-lactic acid-block-γ-aminobutyric acid)

  • 김자원 (부산대학교 헬스테크놀로지학과) ;
  • 김홍성 (부산대학교 바이오소재과학과)
  • Kim, Ja Won (Department of Health Technology, Pusan National University) ;
  • Kim, Hong Sung (Department of Biomaterial Science, Pusan National University)
  • 투고 : 2014.12.20
  • 심사 : 2015.02.04
  • 발행 : 2015.02.28
⟨ 이전 논문 다음 논문 ⟩

초록

Biodegradable block copolymer of poly(L-lactic acid-block-${\gamma}$-aminobutyric acid) were synthesized for the controlled release of ${\gamma}$-aminobutyric acid (GABA), a neurotransmitter. Poly(L-lactic acid-block-${\gamma}$-aminobutyric acid) was prepared by the self-initiative polymerization of 2-pyrrolidone at the activated end group of poly(L-lactic acid), which was substituted with dehydrated 2-pyrrolidone. The molecular structure of the block copolymer was analyzed by FT-IR spectroscopy, 1H NMR spectroscopy, and XRD. The surface energies and biodegradabilities of the block copolymers were tested. The release behavior of GABA from the block copolymer matrices was investigated. The relative quantity of the blocks had an accommodative amplitude in the release of GABA.

키워드

참고문헌

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