The Korean Journal of Community Living Science (한국지역사회생활과학회지)

The Korean Society of Community Living Science (한국지역사회생활과학회)
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Effects of Korean and Chinese Crataegi Fructrus on the Antioxidant Activity and Antiproliferation of Cancer Cells

한국산과 중국산 산사의 항산화 활성 및 암세포 증식 억제효과

  • Park, Yonghyun (Dept. of Food and Nutrition, Chosun University) ;
  • Lee, Hyun-Joo (Dept. of Nutrition and Culinary Science, Hankyoung National University) ;
  • Lee, Jae-Joon (Dept. of Food and Nutrition, Chosun University)
  • 박용현 (조선대학교 식품영양학과) ;
  • 이현주 (한경대학교 영양조리과학과) ;
  • 이재준 (조선대학교 식품영양학과)
  • Received : 2015.01.29
  • Accepted : 2015.02.13
  • Published : 2015.02.27
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Abstract

This study examines the effects of Korean Crataegi fructrus(KCF) and Chinese Crataegi fructrus(CCF) on the antioxidative activity and antiproliferation of human cancer cells(HCT-116 human colon, Hep G2 human liver, and A549 human lung cancer cells). The total polyphenol and flavonoid contents, and antioxidative index of the Crataegi fructrus ethanol extracts were significantly higher in KCF than in CCF. The DPPH radical-scavenging activity of the KCF ethanol extract was 82.26%(1000 ppm), and that of the CCF ethanol extract was 77.64%. Antiproliferation effects of 80% ethanol extracts of KCF and CCF on human cancer cells(HCT-116, Hep G2 and A549) increased in a dose-dependent manner. Inhibitory effects of KFC on HCT-116 and A549 cells were greater than those of CCF. The results suggest that ethanol extracts of Crataegi fructrus have antioxidative and hyperplasia inhibition effects on human cancer cells.

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References

  1. Bae YI, Chung YC, Shim KH(2002) Antimicroial and antioxidant activities of various solvent extract from different parts of loquat(Eriobotrya japonica, Lindl.). Korean J Food Preserv 9(1), 97-101
  2. Ban SS, Yon HD, Shin OC, Shin YJ, Park CS(2006) The effects of Artemisiac capillaris, Ponciri fructus and Cartaegi fructus in obese rats induced by high fat diet. Kor J Herbology 21(3), 55-67
  3. Blois MS(1958) Antioxidant determinations by the use of a stable free radical. Nature 181(9) 1199-1203 https://doi.org/10.1038/1811199a0
  4. Burak Climen MY(2008) Free radical metabolism in human erythrocytes. Clin Chim Acta 390(1-2), 1-11 https://doi.org/10.1016/j.cca.2007.12.025
  5. Central Cancer Registry Center in Korea(2011) Annual report of the Korea central cancer registry. Ministry of Health and Welfare, Korea
  6. Cha GS, Choi CU(1990) Determination of oxidation stability of perilla oil by the Rancimat method. Korean J Food Sci Technol 22(1), 61-65
  7. Cha JY, Cho YS(2001) Biofunctional activities of citrus flavonoids. J Kor Soc Agric Chem Biothchnol 44(2) 122-128
  8. Chae SK, Kang GS, Ma SJ, Bang KW, Oh MW, Oh SH(2002) Standard food analysis. Jigu-Moonwha Sa. pp381-382
  9. Folin O, Denis W(1912) On phosphotungastic phosphomolybdic compounds as color reagents. J Biol Chem 12(2), 239-249
  10. Hwang HS, Kim JM, Jeon YJ, Song YA, Park HS(2003) Flavonoids and antimicrobial activity of the ethanol extract of Korean cherry(Prunus tomentosa Thunberg). J Korean Soc Food Sci Nutr 32(6), 833-839 https://doi.org/10.3746/jkfn.2003.32.6.833
  11. Ishiyama M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno K(1996) A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet. Bio Pharm Bull 19(11), 1518-1520 https://doi.org/10.1248/bpb.19.1518
  12. Jeong TS, Hwang EI, Lee HB, Lee ES, Kim YK, Min BS, Bae KH, Bok SH, Kim SU(1999) Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. Planta Med 65(3), 261-263 https://doi.org/10.1055/s-2006-960474
  13. Joo KJ, Kim JJ(2002) Oxidative stability and flavor compounds of sesame oils blended with vegetable oils. Korean J Food Sci. Technol 34(6), 499-502
  14. Jung GT, Ju IO, Chio DG, Jeong JS, Ryu J, Ko BR, Choi JS, Choi YG(2005) Chemical characteristics and physiological activities of plums (Oishiwase and Formosa). Korean J Food Sci Technol 37(5), 816-821
  15. Kim HJ, Jo CH, Kim TH, Kim DS, Park MY, Byun MW(2006) Biological evaluation of the methanolic extract of Eriobotrya japonica and its irradiation effect. Korean J Food Sci Technol 38(5), 684-690
  16. Kim HJ, Yu MH, Lee SO, Park JH, Par DC, Lee IS(2004) Effects of plum fruits extracts at different growth stages on quinone reductase induction and growth inhibition on cancer cells. J Korean Soc Food. Sci Nutr 33(9), 1445-1450 https://doi.org/10.3746/jkfn.2004.33.9.1445
  17. Kim JH, Kim MU, Cho YJ(2007) Isolation and identification of inhibitory compound from Crataegi fructus on $\alpha$-amylase and $\alpha$-glucosidase. J Korean Soc App Biol Chem 50(3), 204-209
  18. Kim JP, Chon IJ, Cho HK, Ham IH, Whang WK(2004) The antioxidant and the antidiabetic effects of ethanol extract from biofunctional foods prescriptions. Kor J Pharmacogn 35(1), 98-103
  19. Kim JS, Jeong SH(2007) Quality characteristics of bread added with Crataegus pinnatifida bunge powder. J East Asian Soc Dietary Life 17(1), 125-129
  20. Kim JS, Lee GD, Kwon JH, Yoon HS(1993a) Identification of phenolic antioxidative components in Crataegus pinnatifida Bunge. J Korean Agric Chem Soc 36(3), 154-157
  21. Kim JS, Lee GD, Kwon JH, Yoon HS(1993b) Antioxidative effectiveness of ether extract in Crataegus pinnatifida Bunge and Terminalia chebula Rets. J Korean Agric Chem Soc 36(3), 203-207
  22. Lee JH(2002) The effects of Prunus mume ethanol extract on the ethanol-induced hepatotoxicity in rat liver. Master's thesis, Chosun university, Gwangju, Korea
  23. Lee JJ, Lee HJ(2012) Comparisons of physicochemical composition of Korean and Chinese Crataegi fructrus. Korean J Food Preserv 19(4) 569-576 https://doi.org/10.11002/kjfp.2012.19.4.569
  24. Lee JM, Chang PS, Lee JH(2007) Comparison of oxidative stability for the thermally-oxidized vegetable oils using a DPPH method. Korean J Food Sci Technol 39(2), 133-137
  25. Lee MK, Lee HS, Choi GP, Oh DH, Kim JD, Yu CY, Lee HY(2003) Screening of biological activities of the extracts from Rubus coreanus Miq. Korean J Medicinal Crop Sci 11(1), 5-12
  26. Lee MY, Yoo MS, Whang YJ, Jin YJ, Hong MH, Pyo YH(2012) Vitamin C, total polyphenol, flavonoid contents and antioxidant capacity of several fruit peels. Korean J Food Sci Technol 44(5), 540-544 https://doi.org/10.9721/KJFST.2012.44.5.540
  27. Lim JD, Yu CY, Kim MJ, Yun SJ, Lee SJ, Kim NY, Chung IM(2004) Comparison of SOD activity and phenolic compound contents in various Korean medicinal plants. Korean J Medicinal Crop Sci 12(3), 191-202
  28. Liu RH(2003) Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 78(3), 517S-520S
  29. Liu T, Cao Y, Zhao M(2010) Extraction optimization, purification and antioxidant activity of procyanidins from hawthorn(C. pinnatifida Bge. var. major) fruits. Food Chem 119(4), 1656-1662 https://doi.org/10.1016/j.foodchem.2009.09.001
  30. Nakatani N, kayano S, kikuzaki H, Sumino K, Katagiri K, Mitani T(2000) Identification, quantitative determination, and antioxidative activities of chlorogenic acid isomers in prune(Prunus domestica L.). J Agr Food Chem 48(11), 5512- 5516 https://doi.org/10.1021/jf000422s
  31. Oh IS, Kim IH(1993) Pharmaco-constituents of Crataegus pinnatifida var. psilosa leaves(I). Korean J Pharmacogn 37(5), 476-482
  32. Park CS, Yang KM, Kim ML(2006) Functional properties of medicinal plant extracts. Korean J Food Cookery Sci 23(5), 720-727
  33. Park SW, Yook CS, Lee HK(1994) Chemical components from the fruits of Crataegus pinnatifida var. psilosa. Korean J Pharmacogn 25(4), 328-335
  34. Ryu HY, Ahn SM, Kim JS, Jung IC, Sohn HY(2010) Antimicrobial activity of fruit of Crataegus pinnatifida Bunge against multidrug resistant pathogenic Pseudomonas aeruginosa and Candida sp. Korean J Microbiol Biotechnol 38(1), 77-83
  35. Park SJ, Shin EH, Lee JH(2012) Biological activities of solvent fractions from methanolic extract of Crataegi fructus. Korean J Food Nutr 25(4), 897-902 https://doi.org/10.9799/ksfan.2012.25.4.897
  36. Park YS, Park YJ, Kim HJ, Im MH, Lee MK, Kim YM, Cho JY, Heo BG(2008) Physiological activity of ethanol extract from the different plant parts of loquat(Eriobotrya japonica, Lindl.). Kor J Hort Sci Technol 26(1), 75-80
  37. Rice-Evans CA, Miller NJ, Paganga G(1997) Antioxidant properties of phenolic compounds. Trends Plant Sci 2(2), 152-159 https://doi.org/10.1016/S1360-1385(97)01018-2
  38. Ryu MJ, Chung HS(2011) Effects on hot water extract of Schizandra chinensis on colon cancer cell line. Food Engineering Progress 15(1), 64-69
  39. Seol KL, Choi SY, Lee JI(2002) A study on the use, understanding satisfaction with alternative therapy for hospitalized cancer patients. J Korean Public Health Assoc 28(2), 198-211
  40. Shim SM, Choi SW, Bae SJ(2001) Effects of Punica granatum L. fractions on quinone reductase induction and growth inhibition on several cancer cells. J Korean Soc. Food Sci. Nutr 30(1), 80-85
  41. Shin SJ, Yoon HH(2011) Quality characteristics of sansapyun with various amounts of Crataegi fructus concentrate. Korean J Culinary Res 17(3), 181-190
  42. Song TH, Choi HS, Kim YS, Woo IA(2012) Study on sensory and mechanical characteristics of white bread containing different levels of Korean and Chinese Sansa(Crataegus pinatifida Bunge) powder. Korean J Food Culture 27(4), 391-399 https://doi.org/10.7318/KJFC/2012.27.4.391
  43. Stadtman ER, Berlett BS(1998) Reactive oxygenmediated protein oxidation in aging and disease. Drug Metab Rev 30(2) 325-243
  44. Statistics Korea(2012) 2011 cause of death statistics. Statistics Korea. Daejeon, Korea, pp9-10
  45. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J(2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell 39(1), 44-84 https://doi.org/10.1016/j.biocel.2006.07.001
  46. Wang JM(1985) Chinese herbal pharmacology. Shanghai. Shanghai Science & Technology Publisher. pp67-75
  47. Wang RJ, Li DF, Bourne S(2000) Can 2000 years of herbal medicine history helf us solve problems in the year 2000 biotechnology in the feed industry. Proceed. Alltech's 14th Annual Symposium, pp 273-291
  48. Wang SB, Ahn EM, Jung JW(2009) The fruits of Crataegus pinnatifida Bunge ameliorates learning and memory impairments induced by scopolamine. Kor J Herbology 24(4), 165-171
  49. World Health Organization(2012) World health statistics 2012, World Health Organization. Geneva, Switzerland, pp80-81
  50. Yoo SJ, Kim SH, Jun MS, Oh HT. Choi HJ, Ham SS(2007) Antioxidative, antimutagenic and cytotoxic effects of Prunus armeniaca extracts. Korean J Food Preserv 14(2), 220-225
  51. Yoon OH, Jeong BY, Kim EK, Jeong YH(2011) Chemical composition and antioxidant activities of Prunus salicina Formasa produced in Gimcheon. J Korean Soc Food Sci Nutr 40(3), 379-384 https://doi.org/10.3746/jkfn.2011.40.3.379
  52. Yun JH(2000) Effects of Chrysanthemum indicum L. extract in the activity and differentiation of osteoblastic MC3T3-E1 cells. Master's thesis, Duksung Women's University, Seoul, Korea

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