DOI QR코드

DOI QR Code

Relationship among impaired fasting glucose and diabetes and periodontal disease

공복혈당장애 및 당뇨병과 치주질환의 관련성

  • Park, Ji-Hye (Depart. of Dental Hygiene, Daegu Health College)
  • 박지혜 (대구보건대학교 치위생학과)
  • Received : 2014.08.22
  • Accepted : 2015.01.08
  • Published : 2015.01.31

Abstract

This study examined the relationships among impaired fasting glucose (IFG), diabetes and periodontal disease. The data from 10,856 adults (aged over 19 years) was derived from the Fifth Korean National Health and Nutrition Examination Survey, which was conducted in 2010 and 2012. Adjusting the related confounders, multiple logistic regression analysis showed that periodontitis were related to gender, age, education level, smoking and diabetic status (p<0.001). These findings suggest that abnormal fasting glucose, which is a predisposing factor for diabetes mellitus, does not appear to be a risk indicator for periodontal disease. On the other hand, if patients do not take steps to prevent or delay diabetes, prediabetes is likely to develop into type 2 diabetes within 10 years. Therefore, patients with prediabetes need to undergo continuous examinations and management of periodontal disease.

본 연구에서는 공복혈당장애 및 당뇨병과 치주질환의 관련성을 알아보고자 하였다. 본 연구는 국민건강영양조사 제5기(2010년, 2012년) 원시자료를 이용하였으며, 만 19세 이상 성인 총 10,856명을 최종 연구대상자로 선정하였다. 치주질환 유병여부를 종속변수로 한 로지스틱 회귀분석에서는 모든 변수가 보정된 상태에서 성별, 연령, 교육수준, 흡연 및 당뇨병상태가 통계적으로 유의하게 관련이 있는 것으로 나타났다(p<0.001). 본 연구결과 당뇨병의 전단계인 공복혈당장애가 치주질환의 확실한 위험요인으로 보이지는 않지만, 전당뇨병 환자는 당뇨병을 예방하거나 지연시키는 노력을 하지 않으면, 10년 내에 당뇨병으로 발전될 가능성이 높으므로 전당뇨병 단계에서부터 치주질환의 지속적인 검사와 관리가 필요하다고 할 수 있다.

Keywords

References

  1. M. I. Harris, Diabetes in America, pp. 1-13, NIH Publishers, 1995.
  2. Korean national health and nutrition examination survey, Korea health statistics 2012 [internet], Korean national health and nutrition examination survey[cited 2014 Aug., 1], Available From: https://knhanes.cdc.go.kr/knhanes/ index.do. (accessed 2014 Aug., 18)
  3. C. C. Cowie, K. F. Rust, E. S. Ford, M. S. Eberhardt, D. D. Byrd-Holt, C. Li, D. E. Williams, E. W. Gregg, K. E. Bainbridge, S. H. Saydah, L. S. Geiss, "Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006", Diabetes Care, Vol. 32, No. 2, pp. 287-294, 2009. DOI: http://dx.doi.org/10.2337/dc08-1296
  4. A. Poplawska-Kita, K. Siewko, P. Szpak, B. Krol, B. Telejko, P. A. Klimiuk, W. Stokowska, M. Gorska, M. Szelachowska. "Association between type 1 diabetes and periodontal health", Adv Med Sci, Vol. 59, No. 1, pp. 126-131, 2014. DOI: http://dx.doi.org/10.1016/j.advms.2014.01.002
  5. B. A. Dye, "Global periodontal disease epidemiology", Periodontol 2000, Vol. 58, No. 1, pp. 10-25, 2012. DOI: http://dx.doi.org/10.1111/j.1600-0757.2011.00413.x
  6. G. W. Taylor, W. S. Borgnakke, "Periodontal disease: associations with diabetes, glycemic control and complications", Oral Dis, Vol. 14, No. 3, pp. 191-203, 2008. DOI: http://dx.doi.org/10.1111/j.1601-0825.2008.01442.x
  7. G. W. Taylor, "Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective", Ann Periodontol, Vol. 6, No. 1, pp. 99-112, 2001. DOI: http://dx.doi.org/10.1902/annals.2001.6.1.99
  8. P. N. Papapanou, "Periodontal diseases: epidemiology", Ann Periodontol, Vol. 1, No. 1, pp. 1-36, 1996. https://doi.org/10.1902/annals.1996.1.1.1
  9. M. Shlossman, W. C. Knowler, D. J. Pettitt, R. J. Genco, "Type 2 diabetes mellitus and periodontal disease", J Am Dent Assoc, Vol. 121, No. 4, pp. 532-536, 1990. https://doi.org/10.14219/jada.archive.1990.0211
  10. G. W. Taylor, B. A. Burt, M. P. Becker, R. J. Genco, M. Shlossman, W. C. Knowler, D. J. Pettitt, "Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus", J Periodontol, Vol. 67, No. 10, pp. 1085-1093, 1996. DOI: http://dx.doi.org/10.1902/jop.1996.67.10s.1085
  11. J. Katz, M. Y. Flugelman, A. Goldberg, M. Heft, "Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels", J Periodontol, Vol. 73, No. 5, pp. 494-500, 2002. DOI: http://dx.doi.org/10.1902/jop.2002.73.5.494
  12. F. A. Scannapieco, "Position paper of The American Academy of Periodontology: periodontal disease as a potential risk factor for systemic diseases", J Periodontol, Vol. 9, No. 7, pp. 41-50, 1998.
  13. H. Loe, "Periodontal disease. The sixth complication of diabetes mellitus", Diabetes Care, Vol. 16, No. 1, pp. 329-334, 1993. https://doi.org/10.2337/diacare.16.1.329
  14. M. Manoucher-Pour, P. J. Spagnuolo, H. M. Rodman, N. F. Bissada, "Comparison of neutrophil chemotactic response in diabetic patients with mild and severe periodontal disease", J Periodontol, Vol. 52, No. 8, pp. 410-415, 1981. DOI: http://dx.doi.org/10.1902/jop.1981.52.8.410
  15. G. E. Salvi, J. G. Collins, B. Yalda, R. R. Arnold, N. P. Lang, S. Offenbacher, "Monocytic TNF-$\alpha$ secretion patterns in IDDM patients with periodontal diseases", J Clin Periodontol, Vol. 24, No. 1, pp. 8-16, 1997. DOI: http://dx.doi.org/10.1111/j.1600-051X.1997.tb01178.x
  16. B. Willershauschen-Zonchen, C. Lemmen, G. Hamm, "Influence of high glucose concentrations on glycosaminoglycan and collagen synthesis in cultured human gingival fibroblast", J Clin Periodontol, Vol. 18, No. 3, pp. 190-195, 1991. DOI: http://dx.doi.org/10.1111/j.1600-051X.1991.tb01132.x
  17. T. Saito, Y. Shimazaki, Y. Kiyohara, I. Kato, M. Kubo, M. Iida, T. Koga, "The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: the Hisayama study", J Dent Res, Vol. 83, No. 6, pp. 485-490, 2004. https://doi.org/10.1177/154405910408300610
  18. Y. H. Choi, R. E. McKeown, E. J. Mayer-Davis, A. D. Liese, K. B. Song, A. T. Merchant, "Association between periodontitis and impaired fasting glucose and diabetes", Diabetes Care, Vol. 34, No. 2, pp. 381-386, 2011. DOI: http://dx.doi.org/10.2337/dc10-1354
  19. Y. Zadik, R. Bechor, S. Galor, L. Levin, "Periodontal disease might be associated even with impaired fasting glucose", Br Dent J, Vol. 208, No. 1, pp. E20, 2010. DOI: http://dx.doi.org/10.1038/sj.bdj.2010.291
  20. Y. J. Baek, A study of the association between periodontitis and impaired fasting glucose and diabetes", master's Thesis, Yonsei University, Seoul, 2011.
  21. W. S. Eldin, M. Emara, A. Shoker, "Prediabetes: a must to recognise disease state", Int J Clin Pract, Vol. 62, No. 4, pp. 642-648, 2008. DOI: http://dx.doi.org/10.1111/j.1742-1241.2008.01705.x
  22. The Ministry Health and Welfare, The Fifth Korea National Health and Nutrition Examination Survey (KNHANES V), 2012[internet], Korea Centers for Disease Control and Prevention[cited 2014 Aug., 5], Available From: https://knhanes.cdc.go.kr/knhanes. (accessed 2014 Aug., 18)
  23. American Diabetes Association, "Diagnosis and classification of diabetes mellitus", Diabetes Care, Vol. 33, No. Suppl 1, pp. S62-S69, 2010. DOI: http://dx.doi.org/10.2337/dc14-S081
  24. National Institutes of Health, Diagnosis of Diabetes and Prediabetes[Internet], National Institutes of Health, 2014[cited 2014 Jul., 9], Available From: http://diabetes.niddk.nih.gov/dm/pubs/diagnosis/ index.aspx. (accessed 2014 Aug., 18)
  25. A. E. Hatem, Periodontal diseases-a clinician's guide. pp. 215-221, Intech Publishers, 2012. DOI: http://dx.doi.org/10.5772/29272
  26. G. Awuti, K. Younusi, L. Li, H. Upur, J. Ren, "Epidemiological survey on the prevalence of periodontitis and diabetes mellitus in Uyghur adults from rural Hotan area in Xinjiang", Exp Diabetes Res, Vol. 6, No. 1, pp. 1-7, 2012. DOI: http://dx.doi.org/10.1155/2012/758921
  27. A. N. Astrom, J. Rise, "Socio-economic differences in patterns of health and oralhealth behaviour in 25-yearold Norwegians", Clinical Oral Investigation, Vol. 5, No. 2, pp. 122-128, 2001. DOI: http://dx.doi.org/10.1007/s007840000102
  28. W. M. Thomson, D. Locker, "Dental neglect and dental health among 26-year-olds in the Dunedin Multidisciplinary Health and Development Study", Community Dentistry and Oral Epidemiology, Vol. 28, No. 6, pp. 414-418, 2000. DOI: http://dx.doi.org/10.1034/j.1600-0528.2000.028006414.x
  29. J. M. Albandar, "Global risk factors and risk indicators for periodontal diseases", Periodontol 2000, Vol. 29, No. 1, pp. 177-206, 2002. DOI: http://dx.doi.org/10.1034/j.1600-0757.2002.290109.x
  30. J. Bergstrom, S. Eliasson, J. Dock, "A 10-year prospective study of tobacco smoking and periodontal health", J Periodontol, Vol. 71, No. 8, pp. 1338-1347, 2000. DOI: http://dx.doi.org/10.1902/jop.2000.71.8.1338
  31. J. Bergstrom, "Tobacco smoking and risk for periodontal disease", J Clin Periodontol, Vol. 30, No. 2, pp. 107-113, 2003. DOI: http://dx.doi.org/10.1034/j.1600-051X.2003.00272.x
  32. B. Noack, I. Jachmann, S. Roscher, L. Sieber, S. Kopprasch, C. Luck, M. Hanefeld, T. Hoffmann, "Metabolic diseases and their possible link to risk indicators of periodontitis", J Periodontol, Vol. 71, No. 6, pp. 898-903, 2000. DOI: http://dx.doi.org/10.1902/jop.2000.71.6.898
  33. T. Saito, Y. Shimazaki, Y. Kiyohara, I. Kato, M. Kubo, M. Iida, Y. Yamashita, "Relationship between obesity, glucose tolerance, and periodontal disease in Japanese women: the Hisayama study", J Periodontal Res, Vol. 40, No. 4, pp. 346-353, 2005. DOI: http://dx.doi.org/10.1111/j.1600-0765.2005.00813.x
  34. N. Arora, P. N. Papapanou, M. Rosenbaum, D. R. Jr. Jacobs, M. Desvarieux, R. T. Demmer, "Periodontal infection, impaired fasting glucose and impaired glucose tolerance: results from the Continuous National Health and Nutrition Examination Survey 2009-2010", J Clin Periodontol, Vol. 41, No. 7, pp. 643-652, 2014. DOI: http://dx.doi.org/10.1111/jcpe.12258

Cited by

  1. Prevalence and Risk Factors of Type 2 Diabetes According to Gender among Korean Employees vol.16, pp.11, 2015, https://doi.org/10.5762/KAIS.2015.16.11.7589
  2. Oral health and behavior by diabetic status: the fifth Korea national health and nutrition examination survey vol.16, pp.2, 2016, https://doi.org/10.13065/jksdh.2016.16.02.233