The Journal of Korean Society for Radiation Therapy (대한방사선치료학회지)

Korean Society for Radiation Therapy (대한방사선치료학회)
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The study of thermal change by chemoport in radiofrequency hyperthermia

고주파 온열치료시 케모포트의 열적 변화 연구

  • Lee, seung hoon (Department of Radiation Oncology, Chonbuk National University Hospital / Department of Reserch Institute of Clinical Medicine Chonbuk Nation University-Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Lee, sun young (Department of Radiation Oncology, Chonbuk National University Hospital / Department of Reserch Institute of Clinical Medicine Chonbuk Nation University-Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Gim, yang soo (Department of Radiation Oncology, Chonbuk National University Hospital / Department of Reserch Institute of Clinical Medicine Chonbuk Nation University-Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Kwak, Keun tak (Department of Radiation Oncology, Chonbuk National University Hospital / Department of Reserch Institute of Clinical Medicine Chonbuk Nation University-Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Yang, myung sik (Department of Radiation Oncology, Chonbuk National University Hospital / Department of Reserch Institute of Clinical Medicine Chonbuk Nation University-Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Cha, seok yong (Department of Radiation Oncology, Chonbuk National University Hospital / Department of Reserch Institute of Clinical Medicine Chonbuk Nation University-Biomedical Research Institute of Chonbuk National University Hospital)
  • 이승훈 (전북대학교병원 방사선종양학과 / 전북대학교병원 의학생명 연구소) ;
  • 이선영 (전북대학교병원 방사선종양학과 / 전북대학교병원 의학생명 연구소) ;
  • 김양수 (전북대학교병원 방사선종양학과 / 전북대학교병원 의학생명 연구소) ;
  • ;
  • 양명식 (전북대학교병원 방사선종양학과 / 전북대학교병원 의학생명 연구소) ;
  • 차석용 (전북대학교병원 방사선종양학과 / 전북대학교병원 의학생명 연구소)
  • Received : 2015.10.02
  • Accepted : 2015.12.09
  • Published : 2015.12.31
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Abstract

Purpose : This study evaluate the thermal changes caused by use of the chemoport for drug administration and blood sampling during radiofrequency hyperthermia. Materials and Methods : 20cm size of the electrode radio frequency hyperthermia (EHY-2000, Oncotherm KFT, Hungary) was used. The materials of the chemoport in our hospital from currently being used therapy are plastics, metal-containing epoxy and titanium that were made of the diameter 20 cm, height 20 cm insertion of the self-made cylindrical Agar phantom to measure the temperature. Thermoscope(TM-100, Oncotherm Kft, Hungary) and Sim4Life (Ver2.0, Zurich, Switzerland) was compared to the actual measured temperature. Each of the electrode measurement position is the central axis and the central axis side 1.5 cm, 0 cm(surface), 0.5 cm, 1.8 cm, 2.8 cm in depth was respectively measured. The measured temperature is $24.5{\sim}25.5^{\circ}C$, humidity is 30% ~ 32%. In five-minute intervals to measure the output power of 100W, 60 min. Results : In the electrode central axis 2.8 cm depth, the maximum temperature of the case with the unused of the chemoport, plastic, epoxy and titanium were respectively $39.51^{\circ}C$, $39.11^{\circ}C$, $38.81^{\circ}C$, $40.64^{\circ}C$, simulated experimental data were $42.20^{\circ}C$, $41.50^{\circ}C$, $40.70^{\circ}C$, $42.50^{\circ}C$. And in the central axis electrode side 1.5 cm depth 2.8 cm, mesured data were $39.37^{\circ}C$, $39.32^{\circ}C$, $39.20^{\circ}C$, $39.46^{\circ}C$, the simulated experimental data were $42.00^{\circ}C$, $41.80^{\circ}C$, $41.20^{\circ}C$, $42.30^{\circ}C$. Conclusion : The thermal variations were caused by radiofrequency electromagnetic field surrounding the chemoport showed lower than in the case of unused in non-conductive plastic material and epoxy material, the titanum chemoport that made of conductor materials showed a slight differences. This is due to the metal contents in the chemoport and the geometry of the chemoport. And because it uses a low radio frequency bandwidth of the used equipment. That is, although use of the chemoport in this study do not significantly affect the surrounding tissue. That is, because the thermal change is insignificant, it is suggested that the hazard of the chemoport used in this study doesn't need to be considered.

목 적 : 고주파 온열치료 시 약물투여 및 혈액채취에 사용되는 케모포트로 인한 열적 변화를 알아보고자 한다. 대상 및 방법 : 전극 크기 20 cm인 고주파 온열치료기(EHY-2000, Oncotherm Kft, Hungary)를 이용하여 현재 본원에서 사용 중인 케모포트 중 재질이 플라스틱인 소재, 티타늄을 둘러싼 에폭시 소재와 티타늄 소재 케모포트를 자체 제작한 직경 20 cm, 높이 20 cm 원통형 한천(Agar)팬텀에 삽입하여 온도를 측정하였다. 온도측정기(TM-100, Oncotherm Kft, Hungary) 그리고 Sim4Life(Ver2.0, ZMT, Zurich, Switzerland) 프로그램을 사용하여 실제 측정된 온도변화와 비교 분석하였다. 측정위치는 전극 중심축 및 중심축 측면 1.5 cm지점에 각각 0 cm(표면), 0.5 cm, 1.8 cm, 2.8 cm 깊이별로 하였다. 측정조건은 온도 $24.5{\sim}25.5^{\circ}C$, 습도 30 ~ 32%, 출력 전력 100 W로 5분 간격으로 총 60분을 측정 하였다. 결 과 : 케모포트 미사용, 플라스틱, 에폭시 그리고 티타늄 케모포트를 사용한 경우의 최고온도는 전극 중심축 2.8 cm 깊이에서 측정값 $39.51^{\circ}C$, $39.11^{\circ}C$, $38.81^{\circ}C$, $40.64^{\circ}C$와 모의실험값 $42.20^{\circ}C$, $41.50^{\circ}C$, $40.70^{\circ}C$, $42.50^{\circ}C$이며, 전극 중심축 1.5 cm 측면 2.8 cm 깊이에서 측정값 $39.51^{\circ}C$, $39.32^{\circ}C$, $39.20^{\circ}C$, $39.46^{\circ}C$와 모의실험값 $42.00^{\circ}C$, $41.80^{\circ}C$, $41.20^{\circ}C$, $42.30^{\circ}C$이다. 고안 및 결론 : 고주파 전자기장에 의한 케모포트 주위의 열적 변화량은 부도체 물질인 플라스틱과 에폭시 소재에서 미사용의 경우보다 낮게 나타났으며, 도체 물질인 티타늄 케모포트에서는 약간의 차이를 보였다. 이는 케모포트내 금속 함유량 및 기하학적 구조에 의한 것과 이용 장비의 낮은 고주파 대역를 사용함에 있는 것으로 여겨진다. 즉 본 연구에 사용된 케모포트는 열 변화가 미미하여 장해를 고려하지 않아도 된다고 사료된다.

Keywords

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