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Basal Cell Carcinoma in a Domestic Hedgehog

국내 고슴도치에서 발생한 기저세포암종

  • Ko, Kyu-Ryeon (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Hong, Kyung-Hwa (Anyang Animal Hospital) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • 고규련 (제주대학교 수의과대학, 수의과학연구소) ;
  • 홍경화 (안양동물병원) ;
  • 김재훈 (제주대학교 수의과대학, 수의과학연구소)
  • Accepted : 2015.12.09
  • Published : 2015.12.31

Abstract

A 1-year-old female hedgehog was presented with subcutaneous mass in the right forelimb. Grossly, an elevated subcutaneous mass approximately 4 cm in diameter was located in forelimb. Central dark brown area was surrounded by peripheral milky white zone in the cut surface of mass. Histopathologically, numerous neoplastic cells formed irregular cords or sheets in dermis. Most of neoplastic cells showed palisading features to basement membrane with or without central caseous necrosis. These neoplastic cells showed invasive tendency to adjacent tissues. According to immunohistochemistry, the neoplastic cells demonstrated strong positive signals for pancytokeratin, and negative for vimentin. Based on the gross, histopathology and immunohistochemistry, this mass was diagnosed as basal cell carcinoma in a hedgehog.

1세령 암컷 고슴도치의 앞다리 피하에서 종괴가 발견되어 내원하였다. 육안적으로 앞다리 피하종괴는 직경 약 4 cm 크기로 융기되어 있었다. 종괴의 단면상에서 중심 부위는 암적색이었으며, 그 주위에 유백색 결절이 무수히 매몰되어 있었다. 병리조직학적으로 진피층에는 다량의 종양세포들이 불규칙한 줄 또는 시트형태를 이루고 있었다. 대부분의 종양세포들은 기저막에 울타리 모양으로 배열되어 있었으며, 종양세포무리의 중심부에서는 건락괴사를 관찰할 수 있었다. 또한 종양세포들은 주변조직으로의 침습성을 보이고 있었다. 면역조직화학염색을 실시한 결과, 종양세포들은 vimentin에는 음성반응을 보인 반면, pancytokeratin에는 강한 양성반응을 보였다. 이상의 육안적인 특징, 병리조직학적 소견 및 면역조직화학적 검사를 바탕으로 본 증례는 기저세포암종으로 진단하였다.

Keywords

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  1. Staining Characteristics of Mast Cell Tumor in a Hedgehog vol.33, pp.4, 2015, https://doi.org/10.17555/jvc.2016.08.33.4.218