Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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Hyponatremia May Reflect Severe Inflammation in Children with Kawasaki Disease

  • Lee, I Re (Department of Pediatrics, Yonsei University College of Medicine) ;
  • Park, Se Jin (Department of Pediatrics, Ajou University School of Medicine, Daewoo General Hospital) ;
  • Oh, Ji Young (Department of Pediatrics, Yonsei University College of Medicine) ;
  • Jang, Gwang Cheon (Departments of Pediatrics, National Health Insurance System Ilsan Hospital) ;
  • Kim, Uria (Departments of Pediatrics, National Health Insurance System Ilsan Hospital) ;
  • Shin, Jae Il (Department of Pediatrics, Yonsei University College of Medicine) ;
  • Kim, Kee Hyuck (Departments of Pediatrics, National Health Insurance System Ilsan Hospital)
  • Received : 2015.09.20
  • Accepted : 2015.10.25
  • Published : 2015.10.30
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Abstract

Purpose: The aim of the present study was to investigate the risk factors for the development of coronary artery lesions (CALs) and to determine whether hyponatremia is associated with CALs in children with Kawasaki disease (KD). Methods: We retrospectively analyzed the data of 105 children with KD who were admitted to Ilsan Hospital between January 2000 and July 2011. Results: Erythrocyte sedimentation rate (P = 0.013), total bilirubin levels (P = 0.017) were higher and serum sodium levels (P = 0.027) were lower in KD children with CALs than those without. White blood cell (WBC) counts (P = 0.006), neutrophil counts (P = 0.003) were higher and albumin levels (P = 0.009) were lower in KD children with hyponatremia than those without. On multiple logistic regression analysis, hyponatremia (P = 0.024) and intravenous immunoglobulin-resistance (P = 0.024) were independent risk factors for CALs in KD. Furthermore, serum sodium levels were correlated negatively with WBC counts (P = 0.004), neutrophil counts (P < 0.001), total bilirubin levels (P = 0.005) and positively with albumin levels (P = 0.009). Conclusion: Our study indicates that hyponatremia may reflect severe inflammation in children with KD.

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References

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