Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Piperidones from Benzyl Azides and Acetone

  • Han, Junghoon (Department of Chemistry, Pohang University of Science and Technology) ;
  • Rhee, Young Ho (Department of Chemistry, Pohang University of Science and Technology) ;
  • Park, Jaiwook (Department of Chemistry, Pohang University of Science and Technology)
  • Received : 2014.07.21
  • Accepted : 2014.08.04
  • Published : 2014.12.20
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Abstract

A new method for the synthesis of 2,2-dimethyl-6-substituted 4-piperidone was developed; two equivalents of acetone were annulated with N-unsubstituted imines in-situ generated from benzyl azides using a ruthenium catalyst in the presence of $\small{L}$-proline.

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References

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