대한기계학회논문집B (Transactions of the Korean Society of Mechanical Engineers B)

  • 제38권12호
  • /
  • Pages.971-974
  • /
  • 2014
  • /
  • 1226-4881(pISSN)
  • /
  • 2288-5324(eISSN)
대한기계학회 (The Korean Society of Mechanical Engineers)
권호 표지
DOI QR코드

DOI QR Code

공압식 박동형 심실보조장치에서 공압관 내 공기압에 따른 박출량 추정

Estimation of Stroke Volume Based on Air Pressure in Air Tube with Pneumatic Pulsatile Ventricular Assist Device

  • 강유민 (강원대학교 융합시스템공학과) ;
  • 이진홍 (강원대학교 융합시스템공학과) ;
  • 허균 (순천향대학병원 흉부외과) ;
  • 최성욱 (강원대학교 융합시스템공학과)
  • Kang, Yu Min (School of Fusion System Engineering, Kangwon Nat'l Univ.) ;
  • Lee, Jin Hong (School of Fusion System Engineering, Kangwon Nat'l Univ.) ;
  • Her, Keun (Dept. of Cardiovascular and Thoracic Surgery, Soonchunhyang University Hospital) ;
  • Choi, Seong Wook (School of Fusion System Engineering, Kangwon Nat'l Univ.)
  • 투고 : 2014.03.28
  • 심사 : 2014.08.29
  • 발행 : 2014.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

심실보조장치는 심장질환자에게 심장이식까지의 가교로서 사용된다. 공압식 박동형 심실보조장치를 체내에 이식했을 때, 심실보조장치를 통과하는 혈류가 느려질 경우 혈전이 발생할 수 있기 때문에 박출량을 측정하는 것이 중요하다. 심실보조장치의 박출량을 측정하기 위해 각종 센서를 함께 이식할 경우, 감염의 위험성이 커지기 때문에 본 연구에서는 체외에서 측정할 수 있는 공압관 내 압력을 통해 심실보조장치의 상태를 추정하고자 한다. 체외실험을 통해 공압식 박동형 심실보조장치의 공압관 내 차동압력과 심실보조장치 박출량의 상관관계를 계산하였다. Pearson correlation coefficient r=0.623 으로 두 값의 상관관계가 높으며, 박출량 추정값과 측정값에서 오차가 있었지만 공기 분자의 이동에 따른 식을 개발하여 박출량 추정의 정확성을 높일 수 있을 것으로 보인다.

A ventricular assist device (VAD) is used for bridge to heart transplantation and heart diseases. Knowing the status of a pneumatic pulsatile VAD when implanting it into the body is important: when the velocity of blood flow through the VAD is slow, a thrombus may occur, and thrombosis can be fatal to a patient. In order to determine the state of a VAD, various sensors need to be implanted. Because this introduces the risk of infection and difficulties with sensor management, we developed a method for estimating the state of a VAD indirectly via the pressure in an air tube that can be measured in vitro. We compared the measured values to in vitro experimental results. The estimated and measured values showed some errors, but the accuracy can be improved by refining the estimation process to minimize the risk of infection.

키워드

참고문헌

  1. Mathias C. Busch, MD, Michael Haap, MD, Arnt Kristen, MD, Christian S. Haas, MD, 2011, "Asymptomatic Sustained Ventricular Fibrillation in a Patient With Left Ventricular Assist Device," Annals of Emergency Medicine, Vol. 57, No. 1, pp. 25-28. https://doi.org/10.1016/j.annemergmed.2010.05.023
  2. Eric A. Rose, MD, Annetine C. Gelijns, PhD, Alan J. Moskowitz, MD, Daniel F. Heitjan, PhD, Lynne W. Stevenson, MD, Walter Dembitsky, MD, james W. Long, MD, PhD, Deborah D. Ascheim, MD, Anita R. Tierney, MPh, Ronald G. Levitan, MSc, John T. Watson, PhD, and Paul Meier, PhD, 2001, "Long-Term Use of a Left Ventricular Assist Device for End-stage Heart Failure," The New England Journal of Medicine, Vol. 345, No. 20, pp. 1435-1443. https://doi.org/10.1056/NEJMoa012175
  3. Kang, S. M. and Choi, S. W., 2011, "Blood Flow and Pressure Evaluation for a Pulsatile Conduit-Shaped Ventricular Assist Device with Structural Characteristic of Conduit Shape," Trans. Korean Soc. Mech. Eng. B, Vol. 35, No. 11, pp. 1191-1198. https://doi.org/10.3795/KSME-B.2011.35.11.1191
  4. Undar, A., Frazier, O.H. and Charles D. Fraser, Jr., 1999, "Define Pulsatile Perfusion: Quantification in Terms of Energy Equivalent Pressure," Artificial Organs, Vol. 23, No. 8, pp. 712-716. https://doi.org/10.1046/j.1525-1594.1999.06409.x
  5. William L Holman, MD, Jonathan L Skinner, MD, Ken B Waites, MD, Raymond L Benza, MD, David C McGiffin, MD, James K Kirklin, MD, 1999, "Infection During Circulatory Support with Ventricular Assist Devices," The Society of Thoracic Surgeons, Vol. 68, No. 2, pp. 711-716. https://doi.org/10.1016/S0003-4975(99)00529-9
  6. DMMyers, TJ., McGee, MG., Zeluff, BJ., Radovancevic, B. and Frazier, O. H., 1991, "Frequency and Significance of Infections in Patients Receiving Prolonged LVAD Support," ASAIO J, Vol. 37, pp. 283-285.
  7. Daniel J. Goldstein, Nabeel G. El-Amir, Robert C. Ashton, JR, Kathaine Catanese, Eric A. Rose, Howard R. Levin, and Mehmet C. OZ, 1995, "Fungal Infection in Left Ventricular Assist Device Recipients: incidence, Prophylaxis, and Treatment," ASAIO J, Vol. 41, pp. 873-875. https://doi.org/10.1097/00002480-199510000-00010
  8. Eckman, P. M. and John, R., 2012, "Bleeding and Thrombosis in Patients with Continuous-flow Ventricular Assist Devices," American Heart Association, Vol. 125, pp. 3038-3047.
  9. John, R. and Lee, S., 2009, "The Biological Basis of Thrombosis and Bleeding in Patients with Ventricular Assist Device," Journal of Cardiovascular Translational Research, Vol. 2, pp. 63-70. https://doi.org/10.1007/s12265-008-9072-7