The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Role of Ammonia Transporters in the Kidney with Ureteral Obstruction

요로폐쇄 신장에서 암모니아 운반체의 역할

  • Han, Ki-Hwan (Department of Anatomy, Ewha Womans University School of Medicine)
  • 한기환 (이화여자대학교 의학전문대학원 해부학교실)
  • Published : 2014.04.01
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Abstract

Recent studies have identified a new family of ammonia transporters, Rh B glycoprotein (Rhbg) and Rh C glycoprotein (Rhcg). Rhbg and Rhcg are expressed in the collecting duct system of the kidney. Although it remains controversial whether Rhbg contributes to renal ammonia transport, Rhcg expression parallels ammonia excretion in a variety of experimental models. Kim et al. made an animal model of unilateral ureteral obstruction and demonstrated a decrease in urinary ammonia excretion. Immunohistochemistry with quantitative morphometric analysis revealed that total intensity of Rhcg expression significantly decreased in the obstructed kidney, but did not change in the non-obstructed kidney. These results suggest that decreased Rhcg is likely to cause for the impaired renal ammonia excretion in unilateral ureteral obstruction.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea

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