Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지
DOI QR코드

DOI QR Code

An effective method for improving outcomes in patients with a fertilization defect

  • Yoon, Hye Jin (Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital) ;
  • Kim, Hyung Jun (Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital) ;
  • Bae, In Hee (Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital) ;
  • Chae, Soo Jin (Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital) ;
  • Yoon, San Hyun (Maria Research Center) ;
  • Lee, Won Don (Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital) ;
  • Lim, Jin Ho (Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital)
  • Received : 2014.08.04
  • Accepted : 2014.09.16
  • Published : 2014.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

The effect of artificial oocyte activation (AOA) with a calcium ionophore on intracytoplasmic morphologically selected sperm injection (IMSI) was examined in patients with histories of repeated failed implantation attempts. Four singleton pregnancies and one twin pregnancy were obtained after embryos transfer (5/14, 35.7%). Therefore, AOA combined with IMSI can be considered an option for cycles with a fertilization defect and recurrent implantation failures.

Keywords

References

  1. Rybouchkin AV, Van der Straeten F, Quatacker J, De Sutter P, Dhont M. Fertilization and pregnancy after assisted oocyte activation and intracytoplasmic sperm injection in a case of roundheaded sperm associated with deficient oocyte activation capacity. Fertil Steril 1997;68:1144-7. https://doi.org/10.1016/S0015-0282(97)00378-6
  2. Burrello N, Vicari E, Shin P, Agarwal A, De Palma A, Grazioso C, et al. Lower sperm aneuploidy frequency is associated with high pregnancy rates in ICSI programmes. Hum Reprod 2003;18:1371-6. https://doi.org/10.1093/humrep/deg299
  3. Bartoov B, Berkovitz A, Eltes F, Kogosovsky A, Yagoda A, Lederman H, et al. Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection. Fertil Steril 2003;80:1413-9. https://doi.org/10.1016/j.fertnstert.2003.05.016
  4. Bartoov B, Berkovitz A, Eltes F, Kogosowski A, Menezo Y, Barak Y. Real-time fine morphology of motile human sperm cells is associated with IVF-ICSI outcome. J Androl 2002;23:1-8. https://doi.org/10.1002/j.1939-4640.2002.tb02595.x
  5. Yoon HJ, Bae IH, Kim HJ, Jang JM, Hur YS, Kim HK, et al. Analysis of clinical outcomes with respect to spermatozoan origin after artificial oocyte activation with a calcium ionophore. J Assist Reprod Genet 2013;30:1569-75. https://doi.org/10.1007/s10815-013-0110-2
  6. Berkovitz A, Eltes F, Ellenbogen A, Peer S, Feldberg D, Bartoov B. Does the presence of nuclear vacuoles in human sperm selected for ICSI affect pregnancy outcome? Hum Reprod 2006;21:1787-90. https://doi.org/10.1093/humrep/del049
  7. Berkovitz A, Eltes F, Yaari S, Katz N, Barr I, Fishman A, et al. The morphological normalcy of the sperm nucleus and pregnancy rate of intracytoplasmic injection with morphologically selected sperm. Hum Reprod 2005;20:185-90. https://doi.org/10.1093/humrep/deh545
  8. Oliveira JB, Cavagna M, Petersen CG, Mauri AL, Massaro FC, Silva LF, et al. Pregnancy outcomes in women with repeated implantation failures after intracytoplasmic morphologically selected sperm injection (IMSI). Reprod Biol Endocrinol 2011;9:99. https://doi.org/10.1186/1477-7827-9-99
  9. Antinori M, Licata E, Dani G, Cerusico F, Versaci C, d'Angelo D, et al. Intracytoplasmic morphologically selected sperm injection: a prospective randomized trial. Reprod Biomed Online 2008;16:835-41. https://doi.org/10.1016/S1472-6483(10)60150-2
  10. Kim HJ, Yoon HJ, Jang JM, Oh HS, Lee YJ, Lee WD, et al. Comparison between intracytoplasmic sperm injection and intracytoplasmic morphologically selected sperm injection in oligo-astheno-teratozoospermia patients. Clin Exp Reprod Med 2014;41:9-14. https://doi.org/10.5653/cerm.2014.41.1.9

Cited by

  1. Aide à l’activation ovocytaire : Un nouvel atout dans le traitement des infertilités masculines sévères vol.32, pp.2, 2014, https://doi.org/10.1051/medsci/20163202014
  2. Artificial oocyte activation after intracytoplasmic morphologically selected sperm injection: A prospective randomized sibling oocyte study vol.19, pp.4, 2016, https://doi.org/10.1080/14647273.2016.1240374