Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A Quinoline-thiooxorhodamine Conjugate for Fluorescent Hg2+ Recognition in Aqueous Media and Living Cells

  • Tang, Lijun (Department of Chemistry, Liaoning Provincial Key Laboratory for the Synthesis and Application of Functional Compounds, Bohai University) ;
  • Wen, Xin (Department of Chemistry, Liaoning Provincial Key Laboratory for the Synthesis and Application of Functional Compounds, Bohai University) ;
  • Dai, Xin (Department of Chemistry, Liaoning Provincial Key Laboratory for the Synthesis and Application of Functional Compounds, Bohai University) ;
  • Wu, Di (Department of Chemistry, Liaoning Provincial Key Laboratory for the Synthesis and Application of Functional Compounds, Bohai University) ;
  • Huang, Zhenlong (Department of Chemistry, Liaoning Provincial Key Laboratory for the Synthesis and Application of Functional Compounds, Bohai University)
  • Received : 2014.07.07
  • Accepted : 2014.07.30
  • Published : 2014.11.20
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Abstract

A quinoline-thiooxorhodamine conjugate fluorescent sensor (1) has been synthesized. Sensor 1 exhibits high selectivity and sensitivity to $Hg^{2+}$ in $H_2O$/DMSO (95/5, v/v, HEPES 20 mM, pH = 7.4) solution with fluorescence detection. Other tested metal ions do not induce any significant fluorescence intensity changes. Sensor 1 interacts with $Hg^{2+}$ through a 1:1 binding stoichiometry with a good anti-inference ability. In addition, fluorescent imaging of $Hg^{2+}$ in Hela cells is also successfully demonstrated.

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References

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