Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Preliminary Evaluation of the in vitro Efficacy of 1, 2-di (Quinazolin-4-yl) Diselane against SiHa Cervical Cancer Cells

  • Huang, Yin-Jiu (Department of Bioscience, Bengbu Medical College) ;
  • Zhang, Yu-Yuan (Department of Preventive Medicune, Bengbu Medical College) ;
  • Liu, Gang (School of Chemistry and Materials Science, Ludong University) ;
  • Tang, Jie (Scientific Research Center, Bengbu Medical College) ;
  • Hu, Jian-Guo (Scientific Research Center, Bengbu Medical College) ;
  • Feng, Zhen-Zhong (Department of Pathology, Bengbu Medical College) ;
  • Liu, Fang (Faculty of Pharmacy, Bengbu Medical College) ;
  • Wang, Qi-Yi (Scientific Research Center, Bengbu Medical College) ;
  • Li, Dan (Department of Bioscience, Bengbu Medical College)
  • Published : 2014.08.15
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Abstract

Cervical cancer is one the most common malignancies among females. In recent years, its incidence rate has shown a rising trend in some countries so that development of anticancer drugs for cervical cancer is an urgent priority. In our recent anticancer drug discovery screen, 1, 2-di (quinazolin-4-yl)diselane (LG003) was found to possess wide spectrum anticancer efficacy. In the present work, the in vitro anticancer activity of LG003 was evaluated in the SiHa cervical cancer cell line. Compared with commercial anticancer drugs 10-hydroxycamptothecin, epirubicin hydrochloride, taxol and oxaliplatin, LG003 showed better anticancer activity. Furthermore, inhibition effects were time- and dose-dependent. Morphological observation exhibited LG003 treatment results in apoptosis like shrinking and blebbing, and cell membrane damage. Lactate dehydrogenase release assay revealed that LG003 exerts such effects in SiHa cells through a physiology pathway rather than cytotoxicity, which suggests that title compound LG003 can be a potential candidate agent for cervical cancer.

Keywords

References

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