Asian Pacific Journal of Cancer Prevention

  • 제15권16호
  • /
  • Pages.6715-6720
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Genetic Susceptibility to Esophageal Cancer due to CYP1A1 Gene Variant rs4646903 in Tobacco Addicted Patients of Pashtun Ethnicity: a Case Control Study in Khyber Pakhtunkhwa Province of Pakistan

  • Zakiullah, Zakiullah (Department of Pharmacy, Faculty of Life & Environmental Sciences, University of Peshawar) ;
  • Saeed, Muhammad (Department of Pharmacy, Faculty of Life & Environmental Sciences, University of Peshawar) ;
  • Ali, Sajid (Centre of Biotechnology & Microbiology, Faculty of Life & Environmental Sciences, University of Peshawar) ;
  • Javed, Nabila (Institute of Radiotherapy & Nuclear Medicine (IRNUM)) ;
  • Khisroon, Muhammad (Department of Zoology, Faculty of Life & Environmental Sciences, University of Peshawar) ;
  • Muhammad, Basir (Department of Clinical Oncology, BINOR Cancer Hospital) ;
  • Khuda, Fazli (Department of Pharmacy, Faculty of Life & Environmental Sciences, University of Peshawar) ;
  • Ahmad, Saeed (Department of Microbiology & Biotechnology, Faculty of Life & Environmental Sciences, Sarhad University of Science & Information Technology) ;
  • Ismail, Mohammad (Department of Pharmacy, Faculty of Life & Environmental Sciences, University of Peshawar)
  • 발행 : 2014.08.30
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초록

The purpose of this study was to evaluate associations of the CYP1A1 gene variant rs4646903 polymorphism with the risk of developing esophageal cancer (EC). A case-control study was carried out in Pashtun population of Khyber Pakhtunkhwa province of Pakistan in which 140 hospital based EC cases and 196 population based healthy controls exposed to similar environmental conditions were included. A specific method based on the real time polymerase chain reaction (RT-PCR) was used to detect genotypes in case and control groups and results were then analyzed with SPSS version 20. In our population, individuals with CC and TC genotypes of the CYP1A1 rs4646903 polymorphism had significantly higher risk of EC (adjusted odds (OR): 15.709, 95%CI: 6.065-40.686, OR: 3.256 95%CI: 1.902-5.574 respectively). The 'C' allele was strongly associated with the disease (p< 0.0001). Adjusted OR was higher (1.5 times in C/C) in case of variant alleles that show the contribution of environmental and nutritional factors towards the development of EC. Our findings suggest that presence of the 'C' allele of rs4646903 (T>C) may be one of the risk alleles for EC susceptibility in Pashtun population.

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참고문헌

  1. Abbas M, Srivastava K, Imran M, Banerjee M (2014). Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer in a north indian population. Eur J Obstet Gynecol Reprod Biol. 176, 68-74. https://doi.org/10.1016/j.ejogrb.2014.02.036
  2. Afridi SP, Khan A, Waheed I (2000). High risk factors in patient with carcinoma esophagus. J Coll Physicians Surg Pak, 10, 368-70.
  3. Amani F, Ahari SS, Akhghari L (2013). Epidemiology of esophageal cancer in Ardabil province during 2003-2011. Asian Pac J Cancer Prev, 14, 4177-80. https://doi.org/10.7314/APJCP.2013.14.7.4177
  4. Badar F, Anwar N, Mahmood S (2005). Geographical variation in the epidemiology of esophageal cancer in pakistan. Asian Pac J Cancer Prev, 6, 139-42.
  5. Blot W, McLaughlin J, Fraumeni JF (2006). Esophageal Cancer. In Cancer Epidemiology and Prevention Edited by: Schottenfeld D, Fraumeni J. New York: Oxford University Press, 697-706.
  6. Castellsague X, Munoz N, De Stefani E, et al (1999). Independent and joint effects of tobacco smoking and alcohol drinking on the risk of esophageal cancer in men and women. Int J Cancer, 82, 657-64. https://doi.org/10.1002/(SICI)1097-0215(19990827)82:5<657::AID-IJC7>3.0.CO;2-C
  7. Cook MB, Dawsey SM, Freedman ND, et al (2009). Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev, 18, 1174-82. https://doi.org/10.1158/1055-9965.EPI-08-1118
  8. Cortes GR, Villasenor CR (1997). Cancer deesofago. Rev Gastroenterol Mex, 62, 149-59.
  9. D'Errico A, Taioli E, Xhen X, Vineis P (1996). Genetic metabolic polymorphisms and the risk of cancer: a review of the literature. Biomarkers, 1, 149-73. https://doi.org/10.3109/13547509609079352
  10. Eslick G (2009). Epidemiology of esophageal cancer. Gastroenterol Clin N Am, 38, 17-25. https://doi.org/10.1016/j.gtc.2009.01.008
  11. Jamal S, Ahmad M, Khan AH, et al (1997). Carcinoma esophagus-a clinicopathological study of 50 cases at Armed Forces Institute of Pathology, Rawalpindi, Pakistan. J Pathol, 8, 24-8.
  12. Hajmanoochehri F, Mohammadi N, Nasirian N, Hosseinkhani M (2013). Patho-epidemiological features of esophageal and gastric cancers in an endemic region: a 20-year retrospective study. Asian Pac J Cancer Prev, 14, 3491-7. https://doi.org/10.7314/APJCP.2013.14.6.3491
  13. Jamal S (2010). Esophageal cancer in Pakistan-is it really extension of Asian cancer belt? Pak Arm For Med J, 2.
  14. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  15. Kollarova H, Machova L, Horakova D, et al (2007). Epidemiology of esophageal cancer-an overview article. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 151, 17-28. https://doi.org/10.5507/bp.2007.003
  16. Mao WM, Zheng WH, Ling ZQ (2012). Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev, 12, 2461-6.
  17. Moore MA, Tsuda H (2002). Smoking-related research in the Asian-pacific countries. Asian Pac J Cancer Prev, 3, 291-304.
  18. Olshan AF, Weissler MC, Watson MA, Bell DA (2000). GSTM1, GSTT1, GSTP1, CYP1A1, and NAT1 polymorphisms, tobacco use, and the risk of head and neck cancer. Cancer Epidemiol Biomark Prev, 9, 185-91.
  19. Prokopczyk B, Cox JE, Hoffmann D, Waggoner SE (1997). Identification of tobacco specific carcinogen in the cervical mucus of smokers and non-smokers. J Natl Cancer Inst, 89, 868-73. https://doi.org/10.1093/jnci/89.12.868
  20. Sabitha K, Reddy MV, Jamil K (2010). Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer. Cancer Epidemiol, 34, 587-92. https://doi.org/10.1016/j.canep.2010.05.002
  21. Sharma MK, Gour N, Pandey A, Wallia D (2011). Epidemiological study of risk factors for oral, laryngeal and esophageal cancers at a tertiary care hospital in India. Asian Pac J Cancer Prev, 12, 1215-18.
  22. Weng Y, Fei B, He P, Cai M (2012).Glutathione-s-transferase t1 polymorphism is associated with esophageal cancer risk in chinese han population. Asian Pac J Cancer Prev, 13, 4403-07. https://doi.org/10.7314/APJCP.2012.13.9.4403
  23. Taskiran C, Aktas D, Yigit-Celik N, et al (2006). CYP1A1 gene polymorphism as a risk factor for cervical intra epithelial neoplasia and invasive cervical cancer. Gynecol Oncol, 101, 503-6. https://doi.org/10.1016/j.ygyno.2005.11.018
  24. Velema JP, Ferrera A, Figueroa M, et al (2002). Burning wood in the kitchen increases the risk of cervical neoplasia in HPV-infected women in honduras. Int J Cancer, 97, 536-41. https://doi.org/10.1002/ijc.1622
  25. Xia L, Gao J, Liu Y, Wu K, (2013). Significant association between CYP1A1 T3801C polymorphism and cervical neoplasia risk: a systematic review and meta-analysis. Tumor Biol, 34, 223-30. https://doi.org/10.1007/s13277-012-0542-9
  26. Yamaji T, Inoue M, Sasazuki S, et al (2008). Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study. japan public health center-based prospective study group. Int J Cancer, 123, 1935-40. https://doi.org/10.1002/ijc.23744
  27. Yang CX, Wang HY, Wang ZM et al (2005). Risk factors for esophageal cancer: a case control study in southwestern china. Asian Pac J Cancer Prev, 6, 48-53.
  28. Yi SM, Li GY (2012). Null genotype of GSTT1 contributes to esophageal cancer risk in Asian populations: evidence from a meta-analysis. Asian Pacific J Cancer Prev, 13, 4967-71. https://doi.org/10.7314/APJCP.2012.13.10.4967
  29. Yun YX, Wang YP, Wang P, et al (2013). CYP1A1 genetic polymorphisms and risk for esophageal cancer: a casecontrol study in central China. Asian Pac J Cancer Prev, 14, 6507-12. https://doi.org/10.7314/APJCP.2013.14.11.6507
  30. Zakiullah, Saeed M, Muhammad N, et al (2012). Assessment of potential toxicity of smokeless tobacco product (naswar)- available on the pakistani market. Tob.Control, 21, 396-401. https://doi.org/10.1136/tc.2010.042630
  31. Song QK, Zhao L, Li J, et al, (2013). Adverse effects of preserved vegetables on squamous cell carcinoma of esophagus and precancer lesions in a high risk area. Asian Pac J Cancer Prev, 14, 659-63. https://doi.org/10.7314/APJCP.2013.14.2.659

피인용 문헌

  1. Genetic Susceptibility to Oral Cancer due to Combined Effects of GSTT1, GSTM1 and CYP1A1 Gene Variants in Tobacco Addicted Patients of Pashtun Ethnicity of Khyber Pakhtunkhwa Province of Pakistan vol.16, pp.3, 2015, https://doi.org/10.7314/APJCP.2015.16.3.1145
  2. CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case–control study vol.15, pp.2, 2016, https://doi.org/10.1007/s10689-015-9849-1