대한임상독성학회지 (Journal of The Korean Society of Clinical Toxicology)

  • 제12권1호
  • /
  • Pages.8-13
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  • 2014
  • /
  • 1738-1320(pISSN)
  • /
  • 2508-6332(eISSN)
대한임상독성학회 (Korean society of Clincal Toxicology)
권호 표지

자매염색분체교환을 통한 글라이포세이트 유전독성

Genotoxicity of low-dose Glyphosate by Sister Chromatid Exchange

  • 이상훈 (계명대학교 의과대학 동산의료원 응급의학교실) ;
  • 김성진 (계명대학교 의과대학 동산의료원 응급의학교실) ;
  • 최우익 (계명대학교 의과대학 동산의료원 응급의학교실) ;
  • 진상찬 (성균관대학교 의과대학 삼성서울병원 응급의학교실) ;
  • 최인장 (계명대학교 의과대학 해부학교실) ;
  • 이재호 (계명대학교 의과대학 해부학교실)
  • Lee, Sang Hoon (Department of Emergency Medicine, School of Medicine, Keimyung University, Dongsan Medical center) ;
  • Kim, Sung Jin (Department of Emergency Medicine, School of Medicine, Keimyung University, Dongsan Medical center) ;
  • Choi, Woo Ik (Department of Emergency Medicine, School of Medicine, Keimyung University, Dongsan Medical center) ;
  • Jin, Sang Chan (Department of Emergency Medicine, School of Medicine, Sungkyunkwan University, Samsung Medical Center) ;
  • Choi, In Jang (Department of Anatomy, Keimyung University College of Medicine) ;
  • Lee, Jae Ho (Department of Anatomy, Keimyung University College of Medicine)
  • 투고 : 2014.04.28
  • 심사 : 2014.05.27
  • 발행 : 2014.06.30
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초록

Purpose: Glyphosate (N-phosphonomethyl glycine) is widely used as an herbicide for weed control in rural areas. It is also readily available for suicide attempts. Glyphosate has high toxicity and negatively affects the human body. The aim of this investigation was to study the genotoxicity of a low-concentration of glyphosate through sister chromatid exchange (SCE) in human blood lymphocytes in vitro. Methods: Primary lymphocyte cultures were obtained from blood samples of 11 males and seven females who had been exposed to glyphosate (0, 100, 200, and 300 ng/mL). The frequency of SCEs was examined and statistical analysis was performed. Results: All doses of glyphosate induced a significant dose-dependent increase in SCE frequency compared with the control group (P<0.001). In particular, the SCE frequency for exposure to low-dose glyphosate was significantly higher in females than in males. Conclusion: According to the result of this study, even a low-dose of glyphosate may damage DNA and females are more vulnerable to glyphosate.

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